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CLINICAL SIGNIFICANCE OF CEA AND AFP IN THE DETECTION OF MAMMARY CARCINOMAS IN BITCHES

Grant number: 15/15015-9
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2015
Effective date (End): February 28, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:Mirela Tinucci Costa
Grantee:Igor Luiz Salardani Senhorello
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Mammary tumors are very common in bitches and show similar biological behavior to their human counterparts, making the female dog a model to comparative studies. Regarding prognosis, many factors are considered, such as tumor size, regional and distant metastasis, histological diagnosis and others. For relapse monitoring, animals need to be submitted to a periodical series of clinical and image exams, which generates anxiety and additional costs to their owners. There is a lack of accurate methods to monitor disease and determine prognosis in canine mammary tumors. In women, the use of serological markers to determine prognosis is well stablished and that is an useful method to follow up the patient since diagnosis. Thus, the aim of the present study is to evaluate the utilization of serological markers (CEA, CA 15-3 and Alphafetoprotein) in bitches with mammary tumors to stablish its utility as prognosis markers and relapse monitoring in these patients. Results will be evaluated according to the presence and quantification of each marker in the sera of patients, the biological behavior of neoplasia and the occurrence of metastasis and relapse. Statistical analysis will be conducted by Tukey Test (p <0.05).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SENHORELLO, IGOR L. S.; TERRA, ERIKA M.; SUEIRO, FELIPE A. R.; FIRMO, BRUNA F.; ANAI, LETICIA A.; GOLONI, CAMILA; CANAVARI, ISABELA C.; AMPUERO, ROBERTO A. N.; PEREIRA, RODRIGO S.; TINUCCI-COSTA, MIRELA. Clinical value of carcinoembryonic antigen in mammary neoplasms of bitches. VETERINARY AND COMPARATIVE ONCOLOGY, v. 18, n. 3 NOV 2019. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SENHORELLO, Igor Luiz Salardani. Valor clínico do CEA e da AFP na detecção de carcinoma de mama em cadelas. 2017. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Agrárias e Veterinárias..

Please report errors in scientific publications list by writing to: cdi@fapesp.br.