| Texto completo | |
| Autor(es): Mostrar menos - |
Cezar, Marcelo D. M.
[1]
;
Damatto, Ricardo L.
[1]
;
Martinez, Paula F.
[2]
;
Lima, Aline R. R.
[1]
;
Campos, Dijon H. S.
[1]
;
Rosa, Camila M.
[1]
;
Guizoni, Daniele M.
[1]
;
Bonomo, Camila
[1]
;
Cicogna, Antonio C.
[1]
;
Gimenes, Rodrigo
[1]
;
Pagan, Luana U.
[1]
;
Okoshi, Marina P.
[1]
;
Okoshi, Katashi
[1]
Número total de Autores: 13
|
| Afiliação do(s) autor(es): | [1] UNESP, Botucatu Med Sch, BR-18618970 Botucatu, SP - Brazil
[2] Univ Fed Mato Grosso do Sul, Campo Grande - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY; v. 32, n. 5, p. 1275-1287, 2013. |
| Citações Web of Science: | 20 |
| Resumo | |
Background: The role of aldosterone blockers during transition from long-term compensated hypertrophy to dilated failure is not completely understood. In this study we evaluated the effects of early administration of spironolactone on cardiac remodeling, myocardial function, and mortality in spontaneously hypertensive rats (SHR). Methods: Sixteen-month-old SHR received no treatment (SHR-C, n=72) or spironolactone (SHR-SPR, 20 mg/kg/day, n=34) for six months. Echocardiogram was performed before and after treatment. Myocardial function was analyzed in left ventricular (LV) papillary muscle preparations. Myocardial collagen aund hydroxyproline concentration were evaluated by morphometry and spectrophotometry, respectively. LV gene expression was assessed by real time RT-PCR. Statistics: Student's t test; Log rank test (Kaplan Meyer). Results: SHR-C and SHR-SPR presented mortality rates of 71 and 38%, respectively (p=0.004). Systolic arterial pressure did not differ between groups (SHR-C 199 +/- 43; SHR-SPR 200 +/- 35 mmHg). Initial and final echocardiograms did not show significant differences in cardiac structures or LV function between groups. Myocardial function was similar between groups at basal and after inotropic stimulation. Collagen fractional area, hydroxyproline concentration, gene expression for alpha- and beta-myosin heavy chain, atrial natriuretic peptide, and Serca2a were not different between groups. Conclusion: Early spironolactone administration reduces mortality without changing cardiac remodeling in spontaneous hypertensive rats. Copyright (C) 2013 S. Karger AG, Basel (AU) | |
| Processo FAPESP: | 09/54407-9 - Efeitos do bloqueio precoce da aldosterona na estrutura e funcao cardiaca e na composicao da matriz colagena miocardica de ratos espontaneamente hipertensos. |
| Beneficiário: | Marcelo Diarcadia Mariano Cezar |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 07/57497-3 - Efeito do bloqueio da aldosterona na remodelacao cardiaca em ratos espontaneamente hipertensos. |
| Beneficiário: | Marcelo Diarcadia Mariano Cezar |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 09/54506-7 - Efeitos do bloqueio precoce da aldosterona na estrutura e funcao cardiaca e na composicao da matriz colagena miocardica de ratos espontaneamente hipertensos. |
| Beneficiário: | Katashi Okoshi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |