Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Temporal Analysis of Lipopolysaccharide-Induced Sickness Behavior in Virgin and Lactating Female Rats

Texto completo
Autor(es):
Nascimento, Amanda [1] ; Bernardi, Maria [2] ; Pecorari, Vanessa [2] ; Massoco, Christina [1] ; Felicio, Luciano [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Vet Med, Dept Pathol, BR-05508270 Sao Paulo - Brazil
[2] Univ Estadual Paulista, Hlth Sci Inst, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: NEUROIMMUNOMODULATION; v. 20, n. 6, p. 305-312, 2013.
Citações Web of Science: 5
Resumo

Objectives: Lipopolysaccharide (LPS), an endotoxin that originates from the cell wall of Gram-negative bacteria, activates the immune system to release proinflammatory cytokines and to induce sickness behavior. The present study sought to characterize the time-dependent effects of LPS on fever, body weight, and food and water consumption in female virgin and lactating rats exposed to an LPS dose previously reported to induce sickness behavior in pregnant female rats. Methods: Virgin female Wistar rats in the estrous phase and lactating female Wistar rats on the third day of lactation received 100 mu g/kg LPS or saline solution. Tympanic temperature, body weight, and food and water consumption were assessed 0, 2, 24, 48, 72, 96, and 120 h after treatment. Results: In lactating female rats, tympanic temperature was attenuated compared with virgin females. Food consumption and body weight gain in both groups decreased, but lactating rats consumed more food than virgin rats. Water consumption increased at different time points. Conclusion: LPS exposure induced several signs of sickness behavior, including decreases in food consumption and body weight gain, and induced adipsia in both virgin and lactating female rats. Because the time course and profile of fever varied between lactating and nonlactating animals, these responses appeared to depend on the physiological state of female animals. Copyright (C) 2013 S. Karger AG, Basel (AU)

Processo FAPESP: 09/51886-3 - Neuroimunomodulação: fármacos, estresse e citocinas nas relações entre os sistemas nervoso, endócrino e imune
Beneficiário:João Palermo Neto
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 10/01855-1 - Modulação imunológica da relação mãe e filhote
Beneficiário:Amanda Florentina Do Nascimento
Linha de fomento: Bolsas no Brasil - Mestrado