Aluminum as an endocrine disruptor in female Nile tilapia (Oreochromis niloticus)

Autor(es)

Correia, T. G. ^[1] ; Narcizo, A. M. ^[1] ; Bianchini, A. ^[2] ; Moreira, R. G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biociencias, BR-05508090 Sao Paulo - Brazil

^[2] Univ Fed Rio Grande, Inst Ciencias Biol, BR-96201900 Rio Grande, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY; v. 151, n. 4, p. 461-466, May 2010.
• Área do conhecimento: Ciências Biológicas - Fisiologia
• Citações Web of Science: 25
• Assunto(s): Disruptores endócrinos Hidrocortisona Estradiol 17-alfa-Hidroxiprogesterona Alumínio Proteínas Lipídeos

Resumo

The effects of aluminum on plasma ion, lipid, protein and steroid hormone concentration were evaluated in Oreochromis niloticus broodstock females. Lipid and protein concentrations from the gonads and liver were also measured. Experiments were performed at neutral and acidic water pH. Four groups of fish were tested for 96 h: 1) control conditions at neutral water pH; 2) control conditions at acidic water pH (CTR-Ac); 3) aluminum at neutral water pH (Al-N); and 4) aluminum at acidic water pH (Al-Ac). Aluminum and acidic water pH exposure caused no ionoregulatory disturbances. Total lipid concentration increased in the mature gonads and decreased in the liver, suggesting an acceleration of lipid mobilization to the ovaries in animals exposed to aluminum. However, a decreased protein concentration in ovaries was also observed. Exposure of control fish to acidic water pH caused an increased concentration of plasma 17α-hydroxyprogesterone. However, females exposed to aluminum at acidic water pH showed a decreased of plasma 17α-hydroxyprogesterone and cortisol. No differences in plasma 17β-estradiol were observed. The physiological mechanisms underlying the disturbances observed are discussed focusing on reproduction. We suggest that aluminum can be considered an endocrine disrupting compound in mature O. niloticus females. (AU)

• Processo FAPESP: 06/50920-5 - Influência do alumínio e do pH ácido sobre a fisiologia reprodutiva de peixes teleósteos
• Beneficiário: Renata Guimarães Moreira Whitton
• Modalidade de apoio: Auxílio à Pesquisa - Regular