Evaluation of fluoride release from experimental TiF4 and NaF varnishes in vitro

Autor(es)

Livia Picchi COMAR ^[1] ; Beatriz Martines de SOUZA ^[1] ; Larissa Tercilia GRIZZO ^[1] ; Marília Afonso Rabelo BUZALAF ^[4] ; Ana Carolina MAGALHÃES ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, BR-17012901 Bauru, SP - Brazil

^[2] University of São Paulo. Bauru School of Dentistry. Department of Biological Sciences - Brasil

^[3] University of São Paulo. Bauru School of Dentistry. Department of Biological Sciences - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Applied Oral Science; v. 22, n. 2, p. 138-143, 2014-04-00.

Resumo

Fluoride varnishes play an important role in the prevention of dental caries, promoting the inhibition of demineralization and the increase of remineralization. Objective: This study aimed to analyze the amount of fluoride released into water and artificial saliva from experimental TiF4 and NaF varnishes, with different concentrations, for 12 h. Material and Methods: Fluoride varnishes were applied on acrylic blocks and then immersed in 10 ml of deionized water and artificial saliva in polystyrene bottles. The acrylic blocks were divided in seven groups (n=10): 1.55% TiF4 varnish (0.95% F, pH 1.0); 3.10% TiF4 varnish (1.90% F, pH 1.0); 3.10% and 4% TiF4 varnish (2.45% F, pH 1.0); 2.10% NaF varnish (0.95% F, pH 5.0); 4.20% NaF varnish (1.90% F, pH 5.0); 5.42% NaF varnish (2.45% F, pH 5.0) and control (no treatment, n=5). The fluoride release was analyzed after 1/2, 1, 3, 6, 9 and 12 h of exposure. The analysis was performed using an ion-specific electrode coupled to a potentiometer. Two-way ANOVA and Bonferroni's test were applied for the statistical analysis (p<0.05). Results: TiF4 varnishes released larger amounts of fluoride than NaF varnishes during the first 1/2 h, regardless of their concentration; 4% TiF4 varnish released more fluoride than NaF varnishes for the first 6 h. The peak of fluoride release occurred at 3 h. There was a better dose-response relationship among the varnishes exposed to water than to artificial saliva. Conclusions: The 3.10% and 4% TiF4 -based varnishes have greater ability to release fluoride into water and artificial saliva compared to NaF varnish; however, more studies must be conducted to elucidate the mechanism of action of TiF4 varnish on tooth surface. (AU)

• Processo FAPESP: 12/20698-0 - Efeito do TiF4 sobre hidroxiapatita e esmalte submetidos a processos cariogênicos e erosivos: estudos in vitro e in situ
• Beneficiário: Ana Carolina Magalhães
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/07001-4 - Avaliação do efeito de uma pasta experimental com nanosparticulas de fosfato de cálcio sobre a desmineralização de esmalte in vitro
• Beneficiário: Beatriz Martines de Souza
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 11/11263-7 - Avaliação da interação do TiF4 com a hidroxiapatita e esmalte bem como o efeito sobre a des-remineralização do esmalte dentário com lesão de cárie artificial in situ
• Beneficiário: Livia Picchi Comar
• Modalidade de apoio: Bolsas no Brasil - Doutorado