Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Endogenous preoptic hydrogen sulphide attenuates hypoxia- induced hyperventilation

Texto completo
Autor(es):
Kwiatkoski, M. [1] ; Soriano, R. N. [2, 3] ; da Silva, G. S. F. [3] ; Francescato, H. D. [1] ; Coimbra, T. M. [1] ; Glass, M. L. [1] ; Carnio, E. C. [2] ; Branco, L. G. S. [3]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Med Sch Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Nursing Sch Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Dent Sch Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: ACTA PHYSIOLOGICA; v. 210, n. 4, p. 913-927, APR 2014.
Citações Web of Science: 11
Resumo

Aim: We hypothesized that hydrogen sulphide (H2S), acting specifically in the anteroventral preoptic region (AVPO - an important integrating site of thermal and cardiorespiratory responses to hypoxia in which H2S synthesis has been shown to be increased under hypoxic conditions), modulates the hypoxic ventilatory response. Methods: To test this hypothesis, we measured pulmonary ventilation (V-E) and deep body temperature of rats before and after intracerebroventricular (icv) or intra-AVPO microinjection of aminooxyacetate (AOA; CBS inhibitor) or Na2S (H2S donor) followed by 60 min of hypoxia exposure (7% O-2). Furthermore, we assessed the AVPO levels of H2S of rats exposed to hypoxia. Control rats were kept under normoxia. Results: Microinjection of vehicle, AOA or Na2S did not change V-E under normoxic conditions. Hypoxia caused an increase in ventilation, which was potentiated by microinjection of AOA because of a further augmented tidal volume. Conversely, treatment with Na2S significantly attenuated this response. The in vivo H2S data indicated that during hypoxia the lower the deep body temperature the smaller the degree of hyperventilation. Under hypoxia, H2S production was found to be increased in the AVPO, indicating that its production is responsive to hypoxia. The CBS inhibitor attenuated the hypoxia-induced increase in the H2S synthesis, suggesting an endogenous synthesis of the gas. Conclusion: These data provide solid evidence that AVPO H2S production is stimulated by hypoxia, and this gaseous messenger exerts an inhibitory modulation of the hypoxic ventilatory response. It is probable that the H2S modulation of hypoxia-induced hyperventilation is at least in part in proportion to metabolism. (AU)

Processo FAPESP: 11/23339-8 - Participação do sulfeto de hidrogênio (H2S) nas respostas ventilatórias e termo-regulatórias durante hipóxia
Beneficiário:Luiz Guilherme de Siqueira Branco
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/50882-1 - Interação entre óxido nítrico sintase/monóxido de carbono no locus coeruleus durante a resposta febril a endotoxina
Beneficiário:Renato Nery Soriano
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado