Downmodulation of peripheral MOG-specific immunity... - BV FAPESP
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Downmodulation of peripheral MOG-specific immunity by pVAXhsp65 treatment during EAE does not reach the CNS

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Autor(es):
Goncalves Zorzella-Pezavento, Sofia Fernanda [1] ; Chiuso-Minicucci, Fernanda [1] ; Donega Franca, Thais Graziela [1] ; Watanabe Ishikawa, Larissa Lumi [1] ; da Rosa, Larissa Camargo [1] ; Colavite, Priscila Maria [1] ; Marques, Camila [2] ; Valerio Ikoma, Maura Rosane [2] ; Silva, Celio Lopes [3] ; Sartori, Alexandrina [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Dept Microbiol & Immunol, Biosci Inst, BR-18618970 Sao Paulo - Brazil
[2] Fundacao Dr Amaral Carvalho, Lab Citometria Fluxo, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Biochem & Immunol, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Journal of Neuroimmunology; v. 268, n. 1-2, p. 35-42, MAR 15 2014.
Citações Web of Science: 4
Resumo

Most of the therapeutic strategies to control multiple sclerosis are directed to immune modulation and inflammation control. As heat shock proteins are able to induce immunoregulatory T cells, we investigated the therapeutic effect of a genetic vaccine containing the mycobacterial hsp65 gene on experimental autoimmune encephalomyelitis (EAE). Although pVAXhsp65 was immunogenic for mice with EAE and downmodulated specific cytokine induction by MOG, therapy was not able to decrease clinical severity nor to modify immunologic parameters in the CNS. These results indicate that hsp65, administered as a DNA vaccine, was not therapeutic for EAE. (C) 2014 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 11/07528-5 - Proposição de estratégias para controle profilático e terapêutico da encefalite autoimune experimental baseadas no efeito imunorregulador da hsp65
Beneficiário:Alexandrina Sartori
Modalidade de apoio: Auxílio à Pesquisa - Regular