Allele frequency of hereditary equine regional dermal asthenia in American Quarter horses in Brazil determined by quantitative real-time PCR with high resolution melting analysis

Autor(es)

Badial, Peres R. ^[1] ; Oliveira-Filho, Jose P. ^[1] ; Winand, Nena J. ^[2] ; Borges, Alexandre S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, Sao Paulo - Brazil

^[2] Cornell Univ, Coll Vet Med, Dept Mol Med, Ithaca, NY 14853 - USA

• Tipo de documento: Artigo Científico
• Fonte: VETERINARY JOURNAL; v. 199, n. 2, p. 306-307, FEB 2014.
• Citações Web of Science: 4

Resumo

Hereditary equine regional dermal asthenia (HERDA) is a genetic disorder that occurs in the American Quarter horse (AQH) and is caused by a c.115G>A missense mutation in the peptidylprolyl isomerase B (PPIB) gene. Using a quantitative real-time PCR high resolution melting analysis genotyping assay for the PPIB mutation, the estimated HERDA allele and carrier frequencies in a sample of Brazilian AQHs were 2.9% and 5.8%, respectively. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 10/08774-7 - Estudo clínico e molecular da astenia dérmica regional hereditária equina (HERDA)
• Beneficiário: Peres Ramos Badial
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/17764-8 - Estudo clínico e molecular da astenia dérmica regional hereditária equina (HERDA)
• Beneficiário: Alexandre Secorun Borges
• Modalidade de apoio: Auxílio à Pesquisa - Regular