Allele frequency of hereditary equine regional dermal asthenia in American Quarter horses in Brazil determined by quantitative real-time PCR with high resolution melting analysis

Author(s)

Badial, Peres R. ^[1] ; Oliveira-Filho, Jose P. ^[1] ; Winand, Nena J. ^[2] ; Borges, Alexandre S. ^[1]

Affiliation

^[1] Univ Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, Sao Paulo - Brazil

^[2] Cornell Univ, Coll Vet Med, Dept Mol Med, Ithaca, NY 14853 - USA

• Document type: Journal article
• Source: VETERINARY JOURNAL; v. 199, n. 2, p. 306-307, FEB 2014.
• Web of Science Citations: 4

Abstract

Hereditary equine regional dermal asthenia (HERDA) is a genetic disorder that occurs in the American Quarter horse (AQH) and is caused by a c.115G>A missense mutation in the peptidylprolyl isomerase B (PPIB) gene. Using a quantitative real-time PCR high resolution melting analysis genotyping assay for the PPIB mutation, the estimated HERDA allele and carrier frequencies in a sample of Brazilian AQHs were 2.9% and 5.8%, respectively. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 10/08774-7 - Hereditary Equine Regional Dermal Asthenia clinical and molecular study
• Grantee: Peres Ramos Badial
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 09/17764-8 - Hereditary Equine Regional Dermal Asthenia clinical and molecular study
• Grantee: Alexandre Secorun Borges
• Support Opportunities: Regular Research Grants