Anti-trypanosomal Phenolic Derivatives from Baccharis uncinella

Autor(es)

Greeco, Simone dos S. ^{[1, 2]} ; Felix, Maria Julia P. ^[1] ; Lago, Joao Henrique G. ^[1] ; Pinto, Erika G. ^{[3, 4]} ; Tempone, Andre G. ^[5] ; Romoff, Paulete ^[5] ; Ferreira, Marcelo Jose P. ^[5] ; Sartorelli, Patricia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmacet, BR-09972270 Diadema, SP - Brazil

^[2] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-0909040 Santo Andre, SP - Brazil

^[3] Adolfo Lutz Inst, Dept Parasitol, BR-01246000 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Med Trop Sao Paulo, BR-05304000 Sao Paulo - Brazil

^[5] Univ Presbiteriana Mackenzie, Ctr Ciencias & Humanidades, BR-01302907 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT COMMUNICATIONS; v. 9, n. 2, p. 171-173, FEB 2014.
• Citações Web of Science: 11

Resumo

Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a mixture of three chlorogenic acids (3,4-, 3,5- and 4,5-O-dicaffeoylquinic acids), which displayed in vitro anti-trypanosomal activity. Pectolinaringenin, hispidulin and caffeic acid showed activity against trypomastigotes of Trypanosoma cruzi, exhibiting 50% inhibitory concentration (IC50) values of 52, 81 and 56 mu g/mL, respectively, while the chlorogenic acid mixture showed an IC50 value of 61 mu g/mL. The flavonoids and cinnamic acid derivatives were evaluated for cytotoxicity against NCTC cells resulting in a 50% cytotoxic concentration (CC50) ranging from 33.82 to 129.1 mu g/mL while the chlorogenic acids did not display cytotoxicity (CC50 >150 mu g/mL). This is the first report of anti-trypanosomal activity of compounds from B. uncinella. (AU)

• Processo FAPESP: 11/51739-0 - Uso sustentável da biodiversidade de áreas remanescentes da Mata Atlântica do Estado de São Paulo: avaliação, isolamento e caracterização molecular de metabólitos secundários bioativos em espécies vegetais
• Beneficiário: João Henrique Ghilardi Lago
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Regular