Hyperleptinemia: Implications on the Inflammatory State and Vascular Protection in Obese Adolescents Submitted to an Interdisciplinary Therapy

Autor(es):Mostrar menos -

Sanches, Priscila L. ^[1] ; de Mello, Marco T. ^{[2, 1, 3]} ; Elias, Natalia ^[3] ; Fonseca, Francisco A. H. ^[4] ; Campos, Raquel M. S. ^[1] ; Carnier, June ^[1] ; de Piano, Aline ^[1] ; Masquio, Deborah C. L. ^[1] ; Silva, Patricia L. ^[1] ; Oyama, Lila M. ^[5] ; Corgosinho, Flavia C. ^[1] ; Nascimento, Claudia M. O. ^{[5, 1]} ; Tock, Lian ^[6] ; D'Elia, Carolina Ackel ^[1] ; Tufik, Sergio ^{[2, 3]} ; Damaso, Ana R. ^{[7, 1, 8]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Assoc Found Incent Res, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Med, Div Cardiol, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil

^[6] Univ Fed Sao Paulo, Sao Paulo - Brazil

^[7] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil

^[8] Postgrad Program Interdisciplinary Hlth Sci, Santos - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Inflammation; v. 37, n. 1, p. 35-43, FEB 2014.
• Citações Web of Science: 17

Resumo

The low-grade systemic inflammation seen in obesity may affect the actions of some adipose tissue-derived adipokines that are involved in the regulation of vascular function. We sought to verify whether hyperleptinemia may influence the inflammatory and atherogenic responses in obese adolescents undergoing interdisciplinary therapy. Thirty-four obese adolescents underwent interdisciplinary therapy for 1 year. Subjects were considered hyperleptinemic if they had baseline values of leptin above 20 ng/mL for boys and 24 ng/mL for girls. Both groups showed an improvement in body composition and a reduction in carotid intima-media thickness. However, only subjects in the non-hyperleptinemic group showed an increase in adiponectin concentration after therapy. Moreover, leptin concentration was positively correlated with adiponectin and inversely correlated with PAI-1 in this group. Hyperleptinemic state may impair the attenuation of inflammation in obese adolescents undergoing interdisciplinary therapy, particularly by impeding the increase in adiponectin concentration, which is directly involved in vascular protection. (AU)

• Processo FAPESP: 11/50414-0 - Influência da hiperleptinemia nas respostas inflamatórias e aterogênicas em adolescentes obesos
• Beneficiário: Ana Raimunda Dâmaso
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/50356-0 - Análise de complemento protéico plasmático e de fatores de risco metabólicos em adolescentes obesos em tratamento no Centro de Recuperação e Educação Nutricional (CREN)
• Beneficiário: Ana Raimunda Dâmaso
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias
• Beneficiário: Ana Raimunda Dâmaso
• Linha de fomento: Auxílio à Pesquisa - Regular