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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hyperleptinemia: Implications on the Inflammatory State and Vascular Protection in Obese Adolescents Submitted to an Interdisciplinary Therapy

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Author(s):
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Sanches, Priscila L. [1] ; de Mello, Marco T. [2, 1, 3] ; Elias, Natalia [3] ; Fonseca, Francisco A. H. [4] ; Campos, Raquel M. S. [1] ; Carnier, June [1] ; de Piano, Aline [1] ; Masquio, Deborah C. L. [1] ; Silva, Patricia L. [1] ; Oyama, Lila M. [5] ; Corgosinho, Flavia C. [1] ; Nascimento, Claudia M. O. [5, 1] ; Tock, Lian [6] ; D'Elia, Carolina Ackel [1] ; Tufik, Sergio [2, 3] ; Damaso, Ana R. [7, 1, 8]
Total Authors: 16
Affiliation:
[1] Univ Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Assoc Found Incent Res, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Med, Div Cardiol, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil
[6] Univ Fed Sao Paulo, Sao Paulo - Brazil
[7] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil
[8] Postgrad Program Interdisciplinary Hlth Sci, Santos - Brazil
Total Affiliations: 8
Document type: Journal article
Source: Inflammation; v. 37, n. 1, p. 35-43, FEB 2014.
Web of Science Citations: 17
Abstract

The low-grade systemic inflammation seen in obesity may affect the actions of some adipose tissue-derived adipokines that are involved in the regulation of vascular function. We sought to verify whether hyperleptinemia may influence the inflammatory and atherogenic responses in obese adolescents undergoing interdisciplinary therapy. Thirty-four obese adolescents underwent interdisciplinary therapy for 1 year. Subjects were considered hyperleptinemic if they had baseline values of leptin above 20 ng/mL for boys and 24 ng/mL for girls. Both groups showed an improvement in body composition and a reduction in carotid intima-media thickness. However, only subjects in the non-hyperleptinemic group showed an increase in adiponectin concentration after therapy. Moreover, leptin concentration was positively correlated with adiponectin and inversely correlated with PAI-1 in this group. Hyperleptinemic state may impair the attenuation of inflammation in obese adolescents undergoing interdisciplinary therapy, particularly by impeding the increase in adiponectin concentration, which is directly involved in vascular protection. (AU)

FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants