Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents

• Grant number: 11/50414-0
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2011
• End date: September 30, 2013
• Field of knowledge: Health Sciences - Nutrition
• Principal Investigator: Ana Raimunda Dâmaso
• Grantee: Ana Raimunda Dâmaso
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

Currently, obesity is a major public health problem. An estimated 300 million adults and nearly 40 million of children and adolescents worldwide are clinically obese. This increase in obesity in early childhood is associated with the development of many cardiovascular diseases, which highlights the atherosclerosis. Aim: To verify the role of hyperleptinemia on inflammatory and atherogenic response in obese adolescents. (AU)

Scientific publications

(31)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANA CLAUDIA PELISSARI KRAVCHYCHYN; RAQUEL MUNHOZ DA SILVEIRA CAMPOS; YASMIN ALABY MARTINS FERREIRA; SOFIA EMANUELLE DE CASTRO FERREIRA VICENTE; FLÁVIA CAMPOS CORGOSINHO; LILA MISSAE OYAMA; VALTER TADEU BOLDARINE; LIAN TOCK; DAVID THIVEL; ANA RAIMUNDA DÂMASO. O Papel dos Níveis Séricos de ANP na Perda de Peso, Risco Cardiometabólico e Composição Corporal de Adolescentes com Obesidade Submetidos a Terapia Interdisciplinar. Arquivos Brasileiros de Cardiologia, v. 118, n. 1, p. 33-40, 2022-02-21. (15/14309-9, 11/50414-0, 13/08522-6)

DAMASO, ANA RAIMUNDA; DE PIANO, ALINE; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; CORGOSINHO, FLAVIA CAMPOS; SIEGFRIED, WOLFGANG; CARANTI, DANIELLE ARISA; LANDI MASQUIO, DEBORAH CRISTINA; CARNIER, JUNE; SANCHES, PRISCILA DE LIMA; DA SILVA, PATRICIA LEAO; et al. Multidisciplinary Approach to the Treatment of Obese Adolescents: Effects on Cardiovascular Risk Factors, Inflammatory Profile, and Neuroendocrine Regulation of Energy Balance. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2013. (06/00684-3, 11/50414-0)

DE CARVALHO-FERREIRA, JOANA PEREIRA; LANDI MASQUIO, DEBORAH CRISTINA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; NETTO, BARBARA DAL MOLIN; CORGOSINHO, FLAVIA CAMPOS; SANCHES, PRISCILA L.; TOCK, LIAN; TUFIK, SERGIO; DE MELLO, MARCO TULIO; FINLAYSON, GRAHAM; et al. Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys?. Peptides, v. 65, p. 20-28, MAR 2015. (11/50414-0)

LANDI MASQUIO, DEBORAH CRISTINA; GANEN, ALINE DE PIANO; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; SANCHES, PRISCILA DE LIMA; CORGOSINHO, FLAVIA CAMPOS; CARANTI, DANIELLE; TOCK, LIAN; DE MELLO, MARCO TULIO; TUFIK, SERGIO; DAMASO, ANA R.. Cut-off values of waist circumference to predict metabolic syndrome in obese adolescents. NUTRICION HOSPITALARIA, v. 31, n. 4, p. 1540-1550, APR 2015. (11/50414-0)

SANCHES, PRISCILA L.; DE MELLO, MARCO T.; ELIAS, NATALIA; FONSECA, FRANCISCO A. H.; CAMPOS, RAQUEL M. S.; CARNIER, JUNE; DE PIANO, ALINE; MASQUIO, DEBORAH C. L.; SILVA, PATRICIA L.; OYAMA, LILA M.; et al. Hyperleptinemia: Implications on the Inflammatory State and Vascular Protection in Obese Adolescents Submitted to an Interdisciplinary Therapy. Inflammation, v. 37, n. 1, p. 35-43, FEB 2014. (11/50414-0)

ACKEL-D'ELIA, C.; CARNIER, J.; BUENO, JR., C. R.; CAMPOS, R. M. S.; SANCHES, P. L.; CLEMENTE, A. P. G.; TUFIK, S.; DE MELLO, M. T.; DAMASO, A. R.. Effects of Different Physical Exercises on Leptin Concentration in Obese Adolescents. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 35, n. 2, p. 164-171, FEB 2014. (11/50414-0, 06/00684-3)

SANCHES, PRISCILA L.; DE PIANO, ALINE; CAMPOS, RAQUEL M. S.; CARNIER, JUNE; DE MELLO, MARCO T.; ELIAS, NATALIA; FONSECA, FRANCISCO A. H.; MASQUIO, DEBORAH C. L.; DA SILVA, PATRICIA L.; CORGOSINHO, FLAVIA C.; et al. Association of nonalcoholic fatty Liver disease with cardiovascular risk factors in obese adolescents: The role of interdisciplinary therapy. JOURNAL OF CLINICAL LIPIDOLOGY, v. 8, n. 3, p. 265-272, JUN 2014. (11/50414-0)

LIRA, FABIO S.; ROSA, JOSE C.; PIMENTEL, GUSTAVO D.; SANTOS, RONALDO V.; CARNIER, JUNE; SANCHES, PRISCILA L.; DE PIANO, ALINE; DE SOUZA, CLAUDIO T.; TOCK, LIAN; TUFIK, SERGIO; et al. Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents. NUTRITION JOURNAL, v. 11, SEP 18 2012. (11/50414-0)

MASQUIO, D. C. L.; DE PIANO, A.; CAMPOS, R. M. S.; SANCHES, P. L.; CORGOSINHO, F. C.; CARNIER, J.; OYAMA, L. M.; DO NASCIMENTO, C. M. P. O.; DE MELLO, M. T.; TUFIK, S.; et al. Saturated Fatty Acid Intake Can Influence Increase in Plasminogen Activator Inhibitor-1 in Obese Adolescents. Hormone and Metabolic Research, v. 46, n. 4, p. 245-251, APR 2014. (11/50414-0)

DAMASO, ANA RAIMUNDA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; CARANTI, DANIELLE ARISA; DE PIANO, ALINE; FISBERG, MAURO; FOSCHINI, DENIS; SANCHES, PRISCILA DE LIMA; TOCK, LIAN; LEDERMAN, HENRIQUE MANOEL; TUFIK, SERGIO; et al. Aerobic plus resistance training was more effective in improving the visceral adiposity, metabolic profile and inflammatory markers than aerobic training in obese adolescents. JOURNAL OF SPORTS SCIENCES, v. 32, n. 15, p. 1435-1445, 2014. (06/00684-3, 11/50414-0)

CORGOSINHO, FLAVIA CAMPOS; ALMEIDA, SANDRO SOARES; TOCK, LIAN; PESQUERO, JOAO BOSCO; ARAUJO, RONALDO CARVALHO; GROTTI CLEMENTE, ANA PAULA; NETTO, BARBARA DAL'MOLIN; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; DE CARVALHO FERREIRA, JOANA PEREIRA; et al. LEPR polymorphism may affect energy balance during weight loss among Brazilians obese adolescents. Neuropeptides, v. 66, p. 18-24, DEC 2017. (11/50414-0)

PELISSARI KRAVCHYCHYN, ANA CLAUDIA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; MARTINS FERREIRA, YASMIN ALABY; DE CASTRO FERREIRA VICENTE, SOFIA EMANUELLE; CORGOSINHO, FLAVIA CAMPOS; OYAMA, LILA MISSAE; BOLDARINE, VALTER TADEU; TOCK, LIAN; THIVEL, DAVID; DAMASO, ANA RAIMUNDA. he Role of ANP Level Response in Interdisciplinary Weight Loss Therapy on Cardiometabolic Risk and Body Composition in Adolescents with Obesit. Arquivos Brasileiros de Cardiologia, v. 118, n. 1, p. 33-39, 2022. (17/07372-1, 11/50414-0, 15/14309-9)

ROCHE, JOHANNA; CORGOSINHO, FLAVIA CAMPOS; ISACCO, LAURIE; SCHEUERMAIER, KARINE; PEREIRA, BRUNO; GILLET, VALERIE; MOREIRA, GUSTAVO A.; PRADELLA-HALLINAN, MARCIA; TUFIK, SERGIO; DE MELLO, MARCO TULIO; et al. A multidisciplinary weight loss intervention in obese adolescents with and without sleep-disordered breathing improves cardiometabolic health, whether SDB was normalized or not. Sleep Medicine, v. 75, p. 225-235, NOV 2020. (11/50414-0, 13/04136-4, 06/00684-3)

DA SILVEIRA CAMPOS, RAQUEL M.; LANDI MASQUIO, DEBORAH C.; CORGOSINHO, FLVIA CAMPOS; SANCHES, PRISCILA DE LIMA; DE PIANO, ALINE; CARNIER, JUNE; DA SILVA, PATRICIA LEAO; GROTTI CLEMENTE, ANA P.; DE CASTRO FERREIRA VICENTE, SOFIA E.; OYAMA, LILA M.; et al. Homeostasis Model Assessment-Adiponectin: the role of different types of physical exercise in obese adolescents. JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, v. 57, n. 6, p. 831-838, JUN 2017. (15/14309-9, 11/50414-0, 13/08522-6, 13/04136-4)

AGOSTINIS-SOBRINHO, CESAR; RAMIREZ-VELEZ, ROBINSON; NORKIENE, SIGUTE; DAMASO, ANA; GANEN, ALINE DE PIANO; LANDI MASQUIO, DEBORAH C.; RAUCKIEN-MICHAELSSON, ALONA; MOTA, JORGE; SANTOS, RUTE. Association of Adipocytokines and Inflammatory Biomarkers with Blood Pressure in Adolescents: A Longitudinal Analysis. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 30, n. 12, p. 2296-2302, NOV 27 2020. (17/07372-1, 11/50414-0, 15/14309-9, 13/08522-6)

ANA CLAUDIA PELISSARI KRAVCHYCHYN; RAQUEL MUNHOZ DA SILVEIRA CAMPOS; YASMIN ALABY MARTINS FERREIRA; SOFIA EMANUELLE DE CASTRO FERREIRA VICENTE; FLÁVIA CAMPOS CORGOSINHO; LILA MISSAE OYAMA; DAVID THIVEL; LIAN TOCK; ANA RAIMUNDA DÂMASO. Higher increase degree of FGF21 post long-term interdisciplinary weight loss therapy preserves the free fat mass and rest metabolic rate in adolescents with obesity. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 64, n. 4, p. 479-482, 2020-04-06. (13/08522-6, 15/14309-9, 11/50414-0)

ROCHE, J.; CORGOSINHO, F.; DAMASO, A.; SCHEUERMAIER, K.; ISACCO, L.; MIGUET, M.; FILLON, A.; GUYON, A.; MOREIRA, G. A.; PRADELLA-HALLINAN, M.; et al. SLEEP-DISORDERED BREATHING IN ADOLESCENTS WITH OBESITY: WHEN DOES IT START TO AFFECT CARDIOMETABOLIC HEALTH?. Sleep Medicine, v. 64, p. 1-pg., 2019-12-01. (13/04136-4, 06/00684-3, 11/50414-0)

PAULA GROTTI CLEMENTE, ANA; DAL MOLIN NETTO, BARBARA; DI PIANO GANEN, ALINE; TOCK, LIAN; ARISA CARANTI, DANIELLE; TULIO DE MELLO, MARCO; TUFIK, SERGIO; DAMASO, ANA R.. Cut-Off Values of Visceral Adiposity to Predict NAFLD in Brazilian Obese Adolescents. JOURNAL OF NUTRITION AND METABOLISM, v. 2013, p. 8-pg., 2013-01-01. (11/50414-0)

DAMASO, ANA RAIMUNDA; DE PIANO, ALINE; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; CORGOSINHO, FLAVIA CAMPOS; SIEGFRIED, WOLFGANG; CARANTI, DANIELLE ARISA; LANDI MASQUIO, DEBORAH CRISTINA; CARNIER, JUNE; SANCHES, PRISCILA DE LIMA; DA SILVA, PATRICIA LEAO; et al. Multidisciplinary Approach to the Treatment of Obese Adolescents: Effects on Cardiovascular Risk Factors, Inflammatory Profile, and Neuroendocrine Regulation of Energy Balance. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, v. 2013, p. 10-pg., 2013-01-01. (06/00684-3, 11/50414-0)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; CORGOSINHO, FLAVIA CAMPOS; CARANTI, DANIELLE ARISA; GANEN, ALINE DE PIANO; TOCK, LIAN; OYAMA, LILA MISSAE; DAMASO, ANA RAIMUNDA. Effects of magnitude of visceral adipose tissue reduction: Impact on insulin resistance, hyperleptinemia and cardiometabolic risk in adolescents with obesity after long-term weight-loss therapy. Diabetes & Vascular Disease Research, v. 16, n. 2, SI, p. 196-206, MAR 2019. (15/14309-9, 11/50414-0, 13/08522-6, 17/07372-1)

ROCHE, JOHANNA; CORGOSINHO, FLAVIA C.; DAMASO, ANA R.; ISACCO, LAURIE; MIGUET, MAUD; FILLON, ALICIA; GUYON, AURORE; MOREIRA, GUSTAVO A.; PRADELLA-HALLINAN, MARCIA; TUFIK, SERGIO; et al. Sleep-disordered breathing in adolescents with obesity: When does it start to affect cardiometabolic health?. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 30, n. 4, p. 683-693, APR 12 2020. (11/50414-0, 13/04136-4, 06/00684-3)

AGOSTINIS-SOBRINHO, CESAR; DE CASTRO FERREIRA VICENTE, SOFIA EMANUELLE; KIEVISIENE, JUSTINA; LOPES, LUIS; DAMASO, ANA RAIMUNDA; NORKIENE, SIGUTE; ROSARIO, RAFAELA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; RAMIREZ-VELEZ, ROBINSON; MOTA, JORGE; et al. High levels of adiponectin attenuate the detrimental association of adiposity with insulin resistance in adolescents. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 30, n. 5, p. 822-828, MAY 7 2020. (17/07372-1, 15/14309-9, 13/08522-6, 11/50414-0)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; MOREIRA, CARLOS E.; DA SILVA, PATRICIA LEAO; LANDI MASQUIO, DEBORAH C.; CORGOSINHO, FLAVIA CAMPOS; PELISSARI KRAVCHYCHYN, ANA C.; DE CASTRO FERREIRA VICENTE, SOFIA E.; TOCK, LIAN; TUFIK, SERGIO; DE MELLO, MARCO T.; et al. The effect of aerobic plus resistance training associated with a long-term interdisciplinary weight loss program on visceral fat and isokinetic parameters in adolescents with obesity. JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, v. 60, n. 6, p. 855-863, JUN 2020. (11/50414-0, 17/07372-1, 15/14309-9, 13/08522-6)

LANDI MASQUIO, DEBORAH CRISTINA; DE PIANO-GANEN, ALINE; OYAMA, LILA MISSAE; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; SANTAMARINAA, ALINE BOVETO; DE MORAIS HONORATO DE SOUZA, GABRIEL INACIO; GOMES, ALINE DAL'OLIO; MOREIRA, RENATA GUIMARAES; CORGOSINHO, FLAVIA CAMPOS; OLLER DO NASCIMENTO, CLAUDIA MARIA; et al. The role of free fatty acids in the inflammatory and cardiometabolic profile in adolescents with metabolic syndrome engaged in interdisciplinary therapy. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v. 33, p. 136-144, JUL 2016. (11/50414-0)

ALMEIDA, SANDRO S.; CORGOSINHO, FLAVIA C.; AMORIM, CARLOS E. N.; GREGNANI, MARCOS F.; CAMPOS, RAQUEL M. S.; MASQUIO, DEBORAH C. L.; SANCHES, PRISCILA L.; GANEN, ALINE P.; PESQUERO, JOAO B.; DAMASO, ANA R.; et al. Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, v. 18, n. 2, APR-JUN 2017. (15/20082-7, 11/50414-0)

CORGOSINHO, FLAVIA CAMPOS; ACKEL-D'ELIA, CAROLINA; TUFIK, SERGIO; DAMASO, ANA RAIMUNDA; DE PIANO, ALINE; SANCHES, PRISCILA DE LIMA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; SILVA, PATRICIA LEAO; CARNIER, JUNE; TOCK, LIAN; et al. Beneficial Effects of a Multifaceted 1-Year Lifestyle Intervention on Metabolic Abnormalities in Obese Adolescents With and Without Sleep-Disordered Breathing. METABOLIC SYNDROME AND RELATED DISORDERS, v. 13, n. 3, p. 110-118, APR 1 2015. (11/50414-0, 06/00684-3, 13/04136-4)

CAMPOS, RAQUEL M. S.; DE MELLO, MARCO T.; TOCK, LIAN; SILVA, PATRICIA L.; MASQUIO, DEBORAH C. L.; DE PIANO, ALINE; SANCHES, PRISCILA L.; CARNIER, JUNE; CORGOSINHO, FLAVIA C.; FOSCHINI, DENIS; et al. Aerobic Plus Resistance Training Improves Bone Metabolism and Inflammation in Adolescents who Are Obese. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 28, n. 3, p. 758-766, MAR 2014. (06/00684-3, 11/50414-0)

NETTO, BARBARA DAL MOLIN; LANDI MASQUIO, DEBORAH CRISTINA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; SANCHES, PRISCILA DE LIMA; CORGOSINHO, FLAVIA CAMPOS; TOCK, LIAN; OYAMA, LILA MISSAE; DE MELLO, MARCO TULIO; TUFIK, SERGIO; DAMASO, ANA RAIMUNDA. The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents. NUTRICION HOSPITALARIA, v. 29, n. 2, p. 305-314, FEB 2014. (11/50414-0, 13/04136-4)

SANCHES, PRISCILA DE LIMA; DE MELLO, MARCO TULIO; HELFESTEIN FONSECA, FRANCISCO ANTONIO; ELIAS, NATALIA; DE PIANO, ALINE; CARNIER, JUNE; TOCK, LIAN; OYAMA, LILA MISSAE; TUFIK, SERGIO; DAMASO, ANA. Insulin Resistance Can Impair Reduction on Carotid Intima-Media Thickness in Obese Adolescents. Arquivos Brasileiros de Cardiologia, v. 99, n. 4, p. 892-897, OCT 2012. (06/00684-3, 11/50414-0)

KRAVCHYCHYN, A. C. P.; CAMPOS, R. M. S.; DAL, MOLIN NETTO B.; FERREIRA, Y. A.; ABREU, J. D.; OYAMA, L. M.; GANEN, A. P.; CARANTI, D. A.; THIVEL, D.; TOCK, L.; et al. The impact of sugar-sweetened beverage and ultra-processed foods intake on leptin/adiponectin ratio in adolescents with obesity. ANNALS OF NUTRITION AND METABOLISM, v. 79, n. 1, p. 1-pg., 2023-02-01. (15/14309-9, 13/08522-6, 11/50414-0)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; CORGOSINHO, FLAVIA CAMPOS; CARANTI, DANIELLE ARISA; GANEN, ALINE DE PIANO; TOCK, LIAN; OYAMA, LILA MISSAE; DAMASO, ANA RAIMUNDA. Effects of magnitude of visceral adipose tissue reduction: Impact on insulin resistance, hyperleptinemia and cardiometabolic risk in adolescents with obesity after long-term weight-loss therapy. Diabetes & Vascular Disease Research, v. 16, n. 2, p. 11-pg., 2019-03-01. (15/14309-9, 17/07372-1, 13/08522-6, 11/50414-0)