Antioxidant and anti-diabetic potential of Passiflora alata Curtis aqueous leaves extract in type 1 diabetes mellitus (NOD-mice)

Autor(es)

Colomeu, T. C. ^[1] ; Figueiredo, D. ^[1] ; Cazarin, C. B. B. ^[2] ; Schumacher, N. S. G. ^[1] ; Marostica, Jr., M. R. ^[2] ; Meletti, L. M. M. ^[3] ; Zollner, R. L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083887 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, BR-13083862 Campinas, SP - Brazil

^[3] Agron Inst Campinas, BR-13012970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Immunopharmacology; v. 18, n. 1, p. 106-115, JAN 2014.
• Citações Web of Science: 12

Resumo

Leaves of Passiflora alata Curtis were characterized for their antioxidant capacity. Antioxidant analyses of DPPH, FRAP, ABTS, ORAC and phenolic compounds were made in three different extracts: aqueous, methanol/acetone and ethanol. Aqueous extract was found to be the best solvent for recovery of phenolic compounds and antioxidant activity, when compared with methanol/acetone and ethanol. To study the anti-inflammatory properties of this extract in experimental type 1 diabetes, NOD mice were divided into two groups: the P. alata group, treated with aqueous extract of P. alata Curtis, and a non-treated control group, followed by diabetes expression analysis. The consumption of aqueous extract and water ad libitum lasted 28 weeks. The treated-group presented a decrease in diabetes incidence, a low quantity of infiltrative cells in pancreatic islets and increased glutathione in the kidney and liver (p <0.05), when compared with the diabetic and non-diabetic control-groups. In conclusion, our results suggest that the consumption of aqueous extract of P. alata may be considered a good source of natural antioxidants and compounds found in its composition can act as anti-inflammatory agents, helping in the control of diabetes. (C) 2013 Elsevier B.V. All tights reserved. (AU)

• Processo FAPESP: 11/06559-4 - Identificação e caracterização de componentes antiinflamatórios do extrato aquoso de Passiflora alata. Efeito na expressão do diabetes e fatores de regeneração em ilhotas pancreáticas no modelo experimental de diabetes espontâneo tipo 1 (camundongos NOD)
• Beneficiário: Ricardo de Lima Zollner
• Modalidade de apoio: Auxílio à Pesquisa - Regular