Mycoleptones A-C and Polyketides from the Endophyte Mycoleptodiscus indicus

Autor(es):Mostrar menos -

Andrioli, Willian J. ^[1] ; Conti, Raphael ^[1] ; Araujo, Magali J. ^[2] ; Zanasi, Riccardo ^[3] ; Cavalcanti, Bruno C. ^[4] ; Manfrim, Viviane ^[5] ; Toledo, Juliano S. ^[5] ; Tedesco, Daniele ^[6] ; de Moraes, Manoel O. ^[4] ; Pessoa, Claudia ^[4] ; Cruz, Angela K. ^[5] ; Bertucci, Carlo ^[6] ; Sabino, Jose ^[7] ; Nanayakkara, Dhammika N. P. ^[8] ; Pupo, Monica T. ^[1] ; Bastos, Jairo K. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Pernambuco, Dept Antibiot, BR-50670901 Recife, PE - Brazil

^[3] Univ Salerno, Dept Chem & Biol, I-84084 Fisciano - Italy

^[4] Univ Fed Ceara, Dept Fisiol & Farmacol, BR-60430270 Fortaleza, CE - Brazil

^[5] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[6] Univ Bologna, Dept Pharm & Biotechnol, I-40126 Bologna - Italy

^[7] Univ Fed Goias, Inst Fis, BR-74001970 Goiania, Go - Brazil

^[8] Univ Mississippi, Natl Ctr Nat Prod Res, Oxford, MS 38677 - USA

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 77, n. 1, p. 70-78, JAN 2014.
• Citações Web of Science: 7

Resumo

Three new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9-hydroxyeugenin (7), were also isolated. The structural characterization of compounds was carried out by nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, electronic circular dichroism spectroscopy, time-dependent density functional theory calculations, and X-ray crystallography. Compounds 1-9 were weakly active when tested in antileishmanial and cytotoxicity assays. (AU)

• Processo FAPESP: 07/58650-0 - Otimizacao das condicoes de cultivo de beauveria bassiana e fungo endofitico fb59 visando a producao de metabolitos com atividades antimicrobiana, antiparasitaria e antiumoral
• Beneficiário: Willian Jonis Andrioli
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 04/07935-6 - Bioprospecção de fungos: a busca de compostos importantes para o projeto de remédios e enzimas para aplicações farmacêuticas e industriais
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático