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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mycoleptones A-C and Polyketides from the Endophyte Mycoleptodiscus indicus

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Author(s):
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Andrioli, Willian J. [1] ; Conti, Raphael [1] ; Araujo, Magali J. [2] ; Zanasi, Riccardo [3] ; Cavalcanti, Bruno C. [4] ; Manfrim, Viviane [5] ; Toledo, Juliano S. [5] ; Tedesco, Daniele [6] ; de Moraes, Manoel O. [4] ; Pessoa, Claudia [4] ; Cruz, Angela K. [5] ; Bertucci, Carlo [6] ; Sabino, Jose [7] ; Nanayakkara, Dhammika N. P. [8] ; Pupo, Monica T. [1] ; Bastos, Jairo K. [1]
Total Authors: 16
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Fed Pernambuco, Dept Antibiot, BR-50670901 Recife, PE - Brazil
[3] Univ Salerno, Dept Chem & Biol, I-84084 Fisciano - Italy
[4] Univ Fed Ceara, Dept Fisiol & Farmacol, BR-60430270 Fortaleza, CE - Brazil
[5] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[6] Univ Bologna, Dept Pharm & Biotechnol, I-40126 Bologna - Italy
[7] Univ Fed Goias, Inst Fis, BR-74001970 Goiania, Go - Brazil
[8] Univ Mississippi, Natl Ctr Nat Prod Res, Oxford, MS 38677 - USA
Total Affiliations: 8
Document type: Journal article
Source: Journal of Natural Products; v. 77, n. 1, p. 70-78, JAN 2014.
Web of Science Citations: 7
Abstract

Three new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9-hydroxyeugenin (7), were also isolated. The structural characterization of compounds was carried out by nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, electronic circular dichroism spectroscopy, time-dependent density functional theory calculations, and X-ray crystallography. Compounds 1-9 were weakly active when tested in antileishmanial and cytotoxicity assays. (AU)

FAPESP's process: 04/07935-6 - Bioprospection in fungi: the search of lead compounds for drug design and enzymes for pharmaceutical and industrial applications
Grantee:Jairo Kenupp Bastos
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants