| Texto completo | |
| Autor(es): |
Tristao, Fabrine S. M.
[1]
;
Amar, Majid
[1]
;
Latrous, Ines
[1]
;
Del-Bel, Elaine A.
[2, 3]
;
Prediger, Rui D.
[4]
;
Raisman-Vozari, Rita
[1, 5, 6, 7]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] CRICM, UMR 975, INSERM, Paris - France
[2] Univ Sao Paulo, Dept MEF Fisiol, Fac Odontol Ribeirao Preto, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, NAPNA, BR-09500900 Sao Paulo - Brazil
[4] Univ Fed Santa Catarina, Dept Farmacol, Ctr Ciencias Biol, Florianopolis, SC - Brazil
[5] Univ Paris 06, Fac Med, Paris - France
[6] CNRS, UMR, F-7225 Paris - France
[7] Hop La Pitie Salpetriere, Inst Cerveau & Moelle Epiniere, F-75651 Paris 13 - France
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEUROTOXICITY RESEARCH; v. 25, n. 1, p. 24-32, JAN 2014. |
| Citações Web of Science: | 13 |
| Resumo | |
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 1 % of the population older than 60 years. The administration of the proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice is the most widely used approach to elucidate the mechanisms of cell death involved in PD. However, the magnitude of the PD-like neurodegeneration induced by MPTP depends on many variables, including the regimen of its administration. It has been demonstrated that intranasal (i.n.) administration of MPTP constitutes a new route of toxin delivery to the brain that mimics environmental exposure to neurotoxins. Previous data showed that mice submitted to chronic and acute i.n. MPTP treatment displayed a robust (similar to 80 %) and moderate (similar to 55 %) loss of striatal dopamine, respectively. However, little is known about the neurodegenerative and neuroinflammatory processes following a subacute i.n. MPTP administration in mice. Here, the C57BL/6 mice were infused intranasally with MPTP (1 mg/nostril/day) during 4 consecutive days. At 7 and 28 days after the last administration, the subacute i.n. MPTP regime decreased the tyrosine hydroxylase (TH)-labeling in the striatum (40-50 %) and substantia nigra (25-30 %) and increased the astrogliosis in such brain areas at both time points. Taken together, our data showed that the subacute administration of MPTP into the nasal cavity of C57BL/6 mice induces long-lasting neurodegeneration and neuroinflammation in the nigrostriatal pathway, thus representing a valuable animal model for the investigation of neuroprotective strategies in PD. (AU) | |
| Processo FAPESP: | 08/55092-9 - Analysis of nitric oxide synthase in dopaminergic and non dopaminergic neurons in experimental parkinson disease: role of nos inhibitors in i-dopa induced diskinesias (fapesp-inserm) |
| Beneficiário: | Elaine Aparecida Del Bel Belluz Guimarães |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 12/17626-7 - Mecanismos celulares e moleculares envolvidos no papel de neurotransmissores atípicos em transtornos neuropsiquiátricos |
| Beneficiário: | Francisco Silveira Guimaraes |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |