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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Progesterone as a morphological regulatory factor of the male and female gerbil prostate

Texto completo
Autor(es):
Fochi, Ricardo A. [1] ; Santos, Fernanda C. A. [2] ; Goes, Rejane M. [3] ; Taboga, Sebastiao R. [3]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] State Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Sao Paulo - Brazil
[2] Fed Univ Goias UFG, Inst Biol Sci, Dept Morphol, Goiania, Go - Brazil
[3] Univ Estadual Paulista UNESP, Inst Biosci Humanities & Exact Sci IBILCE, Dept Biol, BR-15054000 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: International Journal of Experimental Pathology; v. 94, n. 6, p. 373-386, DEC 2013.
Citações Web of Science: 11
Resumo

Testosterone (T) and oestrogen are the main active steroid hormones in the male and female reproductive system respectively. In female rodents progesterone (P4), together with testosterone and oestrogen, has an essential role in the regulation of the oestrous cycle, which influences the prostate physiology through their oscillations. In this work we investigated how the male and female prostate gland of Mongolian gerbils responds to surgical castration at the start of puberty and what are the effects of T, oestradiol (E2) and P4 replacement, using both quantitative and qualitative methods. We also examined the location of the main steroid receptors present in the prostate. In the castrated animals of both sexes an intense glandular regression, along with disorganization of the stromal compartment, and abundant hyperplasia was observed. The replacement of P4 secured a mild recovery of the glandular morphology, inducing the growth of secretory cells and restoring the androgen receptor (AR) cells. The administration of P4 and E2 eliminated epithelial hyperplasia and intensified gland hypertrophy, favouring the emergence of prostatic intraepithelial neoplasia (PIN). In animals treated with T and P4, even though there are some inflammatory foci and other lesions, the prostate gland revealed morphology closer to that of control animals. In summary, through the administration of P4, we could demonstrate that this hormone has anabolic characteristics, promoting hyperplasia and hypertrophy, mainly in the epithelial compartment. When combined with E2 and T, there is an accentuation of glandular hypertrophy that interrupts the development of hyperplasia and ensures the presence of a less dysplastic glandular morphology. (AU)

Processo FAPESP: 08/11386-9 - Influência da progesterona sobre a próstata do gerbilo (Meriones Unguiculatus): interações com o estrógeno e com a testosterona
Beneficiário:Ricardo Alexandre Fochi
Linha de fomento: Bolsas no Brasil - Doutorado