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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Default Mode, Executive Function, and Language Functional Connectivity Networks are Compromised in Mild Alzheimer's Disease

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Autor(es):
Weiler, Marina [1] ; Fukuda, Aya [1] ; Massabki, Lilian H. P. [1] ; Lopes, Tatila M. [1] ; Franco, Alexandre R. [2] ; Damasceno, Benito P. [3] ; Cendes, Fernando [1] ; Balthazar, Marcio L. F. [1, 3]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Campinas UNICAMP, Dept Neurol, Neuroimaging Lab, BR-13083970 Campinas, SP - Brazil
[2] Catholic Univ Rio Grande Sul PUCRS, Brain Inst Rio Grande Sul, Porto Alegre, RS - Brazil
[3] Univ Campinas UNICAMP, Dept Neurol, Unit Neuropsychol & Neurolinguist, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Current Alzheimer Research; v. 11, n. 3, p. 274-282, MAR 2014.
Citações Web of Science: 18
Resumo

Alzheimer's disease (AD) is characterized by mental and cognitive problems, particularly with memory, language, visuospatial skills (VS), and executive functions (EF). Advances in the neuroimaging of AD have highlighted dysfunctions in functional connectivity networks (FCNs), especially in the memory related default mode network (DMN). However, little is known about the integrity and clinical significance of FNCs that process other cognitive functions than memory. We evaluated 22 patients with mild AD and 26 healthy controls through a resting state functional MRI scan. We aimed to identify different FCNs: the DMN, language, EF, and VS. Seed-based functional connectivity was calculated by placing a seed in the DMN (posterior cingulate cortex), language (Broca's and Wernicke's areas), EF (right and left dorsolateral prefrontal cortex), and VS networks (right and left associative visual cortex). We also performed regression analyses between individual connectivity maps for the different FCNs and the scores on cognitive tests. We found areas with significant decreases in functional connectivity in patients with mild AD in the DMN and Wernicke's area compared with controls. Increased connectivity in patients was observed in the EF network. Regarding multiple linear regression analyses, a significant correlation was only observed between the connectivity of the DMN and episodic memory (delayed recall) scores. In conclusion, functional connectivity alterations in mild AD are not restricted to the DMN. Other FCNs related to language and EF may be altered. However, we only found significant correlations between cognition and functional connectivity in the DMN and episodic memory performance. (AU)

Processo FAPESP: 13/10431-9 - Avaliação da conectividade anatômica e funcional nas redes Default Mode e Salience na demência da Doença de Alzheimer leve e comprometimento cognitivo leve amnéstico
Beneficiário:Marina Weiler
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 11/17092-0 - Biomarcadores na Doença de Alzheimer e comprometimento cognitivo leve: estudo de métodos de ressonância magnética funcional e marcadores liquóricos e plasmáticos
Beneficiário:Marcio Luiz Figueredo Balthazar
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores