Developing electrodes chemically modified with cucurbit[6]uril to detect 3,4-methylenedioxymethamphetamine (MDMA) by voltammetry

Autor(es)

Tadini, Maraine Catarina ^[1] ; Balbino, Marco Antonio ^[1] ; Eleoterio, Izabel Cristina ^[1] ; de Oliveira, Laura Siqueira ^[1] ; Dias, Luis Gustavo ^[1] ; Demets, Gregoire Jean-Francois ^[1] ; de Oliveira, Marcelo Firmino ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Electrochimica Acta; v. 121, p. 188-193, MAR 1 2014.
• Citações Web of Science: 16

Resumo

This study aimed to develop an electrode chemically modified with cucurbit{[}6]uril to detect 3,4-methylenedioxymethamphetamine (MDMA), the main active principle of ecstasy samples, by voltammetry. We modified the electrode surface with a film containing cucurbit{[}6]uril, Nafion, and methanol, using the dip coating or the spin coating technique. During analysis, we employed an electrochemical cell with a conventional three-electrode system and KCl solution (0.1 mol L-1) as the supporting electrolyte. We conducted cyclic voltammetry at concentrations ranging from 4.2 x 10(-6) to 4.8 x 10(-5)mol L-1. We also accomplished scanning electron microscopy, to investigate the structural behavior of the film that originated on the electrode surface. We obtained the following results when we used dip coating to prepare the modified electrode: standard deviation (SD) = 0.024 mu A, limit of detection (LOD) = 3.5 mu mol L-1, limit of quantification (LOQ) = 11.7 mu mol L-1, and amperometric sensitivity (m) = 20.9 x 10(3) mu A L mol(-1). As for spin coating, we obtained SD = 0.024 mu A, LOD =2.7 mu mol L-1, LOQ = 9.1 mu mol L-1 and m = 25.9 x 10(3) mu A mol L-1. These are very promising data: the modified electrode is more sensitive than the conventional glassy carbon electrode under the studied experimental conditions. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 12/17602-0 - Desenvolvimento de eletrodos quimicamente modificados por cucurbiturilas, para a detecção voltamétrica de 3,4-metilenodioximetanfetamina (MDMA)
• Beneficiário: Maraine Catarina Tadini
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/00084-7 - Desenvolvimento de eletrodos quimicamente modificados para a determinação voltamétrica de cocaína, MDMA, LSD e D-9-tetraidrocanabinol em amostras de interesse judicial
• Beneficiário: Marcelo Firmino de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular