Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium

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Marks, Morgan A. ^[1] ; Chaturvedi, Anil K. ^[1] ; Kelsey, Karl ^[2] ; Straif, Kurt ^[3] ; Berthiller, Julien ^{[3, 4, 5]} ; Schwartz, Stephen M. ^[6] ; Smith, Elaine ^[7] ; Wyss, Annah ^[8] ; Brennan, Paul ^[3] ; Olshan, Andrew F. ^[8] ; Wei, Qingyi ^[9] ; Sturgis, Erich M. ^[9] ; Zhang, Zuo-Feng ^[10] ; Morgenstern, Hal ^{[11, 12]} ; Muscat, Joshua ^[13] ; Lazarus, Philip ^[13] ; McClean, Michael ^[14] ; Chen, Chu ^[6] ; Vaughan, Thomas L. ^[6] ; Wunsch-Filho, Victor ^[15] ; Curado, Maria Paula ^[16] ; Koifman, Sergio ^[17] ; Matos, Elena ^[18] ; Menezes, Ana ^[19] ; Daudt, Alexander W. ^[20] ; Fernandez, Leticia ^[21] ; Posner, Marshall ^[22] ; Boffetta, Paolo ^{[23, 16]} ; Lee, Yuan-Chin Amy ^[24] ; Hashibe, Mia ^[24] ; D'Souza, Gypsyamber ^[25]

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^[1] NCI, Div Canc Epidemiol & Genet, Rockville, MD - USA

^[2] Brown Univ, Sch Med, Dept Community Hlth, Providence, RI 02912 - USA

^[3] Int Agcy Res Canc, F-69372 Lyon - France

^[4] Hosp Civils Lyon, Lyon - France

^[5] Univ Lyon 1, Equipe Accueil 4129, F-69365 Lyon - France

^[6] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 - USA

^[7] Univ Iowa, Coll Publ Hlth, Iowa City, IA - USA

^[8] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC - USA

^[9] Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg & Epidemiol, Houston, TX 77030 - USA

^[10] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 - USA

^[11] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 - USA

^[12] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 - USA

^[13] Penn State Coll Med, Hershey, PA - USA

^[14] Boston Univ, Sch Publ Hlth, Boston, MA - USA

^[15] Univ Sao Paulo, Fac Saude Publ, Sao Paulo - Brazil

^[16] Int Prevent Res Inst, Lyon - France

^[17] Fundacao Oswaldo Cruz, Escola Nacl Saude Publ, Rio De Janeiro - Brazil

^[18] Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF - Argentina

^[19] Univ Fed Pelotas, Pelotas - Brazil

^[20] Hosp Clin Porto Alegre, Port Alegre - Brazil

^[21] Inst Oncol & Radiobiol, Havana - Cuba

^[22] Johns Hopkins Sch Med, Baltimore, MD - USA

^[23] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY - USA

^[24] Univ Utah, Sch Med, Salt Lake City, UT - USA

^[25] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 - USA

• Tipo de documento: Artigo Científico
• Fonte: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION; v. 23, n. 1, p. 160-171, JAN 2014.
• Citações Web of Science: 20

Resumo

Background: The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950. Methods: A pooled analysis was conducted comprising individual-level data from nine case-control studies from the United States and Latin America in the INHANCE consortium. Self-reported information on marijuana smoking, demographic, and behavioral factors was obtained from 1,921 oropharyngeal cases, 356 oral tongue cases, and 7,639 controls. Results: Compared with never marijuana smokers, ever marijuana smokers had an elevated risk of oropharyngeal {[}adjusted OR (aOR), 1.24; 95% confidence interval (CI): 1.06-1.47] and a reduced risk of oral tongue cancer (aOR, 0.47; 95% CI, 0.29, 0.75). The risk of oropharyngeal cancer remained elevated among never tobacco and alcohol users. The risk of oral tongue cancer was reduced among never users of tobacco and alcohol. Sensitivity analysis adjusting for potential confounding by HPV exposure attenuated the association of marijuana use with oropharyngeal cancer (aOR, 0.99; 95% CI, 0.71-1.25), but had no effect on the oral tongue cancer association. Conclusions: These results suggest that the association of marijuana use with head and neck carcinoma may differ by tumor site. Impact: The associations of marijuana use with oropharyngeal and oral tongue cancer are consistent with both possible pro-and anticarcinogenic effects of cannabinoids. Additional work is needed to rule out various sources of bias, including residual confounding by HPV infection and misclassification of marijuana exposure. (C) 2013 AACR. (AU)

• Processo FAPESP: 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe
• Beneficiário: José Eluf Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular