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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Genome-wide association analysis of feed intake and residual feed intake in Nellore cattle

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Autor(es):
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Santana, Miguel H. A. [1] ; Utsunomiya, Yuri T. [2] ; Neves, Haroldo H. R. [2] ; Gomes, Rodrigo C. [3] ; Garcia, Jose F. [2, 4] ; Fukumasu, Heidge [1] ; Silva, Saulo L. [1] ; Oliveira Junior, Gerson A. [1] ; Alexandre, Pamela A. [1] ; Leme, Paulo R. [1] ; Brassaloti, Ricardo A. [5] ; Coutinho, Luiz L. [5] ; Lopes, Thiago G. [2] ; Meirelles, Flavio V. [1] ; Eler, Joanir P. [1] ; Ferraz, Jose B. S. [1]
Número total de Autores: 16
Afiliação do(s) autor(es):
[1] Fac Zootecnia & Engn Alimentos USP, BR-13635900 Sao Paulo - Brazil
[2] UNESP Univ Estadual Paulista, Fac Ciencias Agr & Vet, BR-14884900 Sao Paulo - Brazil
[3] Empresa Brasileira Pesquisa Agropecuaria, CNPGC EMBRAPA, BR-79002970 Campo Grande, Matogrosso Do S - Brazil
[4] UNESP Univ Estadual Paulista, Fac Med Vet Aracatuba, BR-16050680 Sao Paulo - Brazil
[5] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, BR-13418900 Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: BMC GENETICS; v. 15, FEB 11 2014.
Citações Web of Science: 30
Resumo

Background: Feed intake plays an important economic role in beef cattle, and is related with feed efficiency, weight gain and carcass traits. However, the phenotypes collected for dry matter intake and feed efficiency are scarce when compared with other measures such as weight gain and carcass traits. The use of genomic information can improve the power of inference of studies on these measures, identifying genomic regions that affect these phenotypes. This work performed the genome-wide association study (GWAS) for dry matter intake (DMI) and residual feed intake (RFI) of 720 Nellore cattle (Bos taurus indicus). Results: In general, no genomic region extremely associated with both phenotypic traits was observed, as expected for the variables that have their regulation controlled by many genes. Three SNPs surpassed the threshold for the Bonferroni multiple test for DMI and two SNPs for RFI. These markers are located on chromosomes 4, 8, 14 and 21 in regions near genes regulating appetite and ion transport and close to important QTL as previously reported to RFI and DMI, thus corroborating the literature that points these two processes as important in the physiological regulation of intake and feed efficiency. Conclusions: This study showed the first GWAS of DMI to identify genomic regions associated with feed intake and efficiency in Nellore cattle. Some genes and QTLs previously described for DMI and RFI, in other subspecies (Bos taurus taurus), that influences these phenotypes are confirmed in this study. (AU)

Processo FAPESP: 11/16643-2 - Estudo de associação genômica para a detecção de regiões cromossômicas relacionadas ao perímetro escrotal de bovinos Nelore
Beneficiário:Yuri Tani Utsunomiya
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 12/03551-5 - Estudo genômico da ingestão e eficiência alimentar em bovinos da raça Nelore
Beneficiário:Miguel Henrique de Almeida Santana
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 12/02039-9 - Estudo genômico da ingestão e eficiência alimentar em bovinos da raça Nelore
Beneficiário:José Bento Sterman Ferraz
Linha de fomento: Auxílio à Pesquisa - Regular