Low intensity resistance training improves systolic function and cardiovascular autonomic control in diabetic rats

Autor(es)

Mostarda, Cristiano T. ^[1] ; Rodrigues, Bruno ^[2] ; de Moraes, Oscar Albuquerque ^{[1, 3]} ; Moraes-Silva, Ivana C. ^[1] ; Olinto Arruda, Paula Barros ^[1] ; Cardoso, Ruymar ^[1] ; Scapini, Katia Bilhar ^[1] ; dos Santos, Fernando ^[1] ; De Angelis, Katia ^[3] ; Irigoyen, Maria Claudia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, BR-05403000 Sao Paulo - Brazil

^[2] Univ Sao Judas Tadeu UST, Human Movement Lab, Sao Paulo - Brazil

^[3] Univ Nove Julho UNINOVE, Translat Physiol Lab, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DIABETES AND ITS COMPLICATIONS; v. 28, n. 3, p. 273-278, MAY-JUN 2014.
• Citações Web of Science: 9

Resumo

Aims: We evaluated the effects of low intensity resistance training (RT) on left ventricular (LV) function, baroreflex sensitivity (BRS), and cardiovascular autonomic control of streptozotocin-induced diabetic rats. Methods: Male Wistar rats were divided into (n = 8 each group): sedentary control (SC), trained control (TC), sedentary diabetic (SD), and trained diabetic (TD). Trained groups underwent low intensity RT (40%-50% 1 repetition maximum) for 10 weeks. Echocardiographic evaluation, arterial pressure (AP), heart rate (HR), BRS, and autonomic measurements were performed. Results: Diabetes induced an increase in glycemia and a reduction in body weight in diabetics when compared with control animals. Diabetic rats displayed cardiac dysfunction, reduced systolic AP and HR, impaired BRS and autonomic derangement when compared to control rats. RT improved ejection fraction (SD: 68% +/- 1.3% vs. TD: 75% +/- 3.0%) and velocity of circumferential fiber shortening (SD: 0.32 +/- 0.02 vs. TD: 0.40 +/- 0.01 circ/seg.10(-4)). Trained diabetic rats presented increased AP (+10.2%), HR (+10.4%), and BRS after RT protocol. Conclusions: Low intensity RT induced an increase in systolic function in diabetic rats. This may be due to positive LV remodeling and BRS improvement, which may have played an important role in the attenuation of hemodynamic impairment and cardiac autonomic neuropathy in streptozotocin-diabetic rats. (C) 2014 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 12/20141-5 - Efeitos do treinamento físico aeróbio, resistido ou combinado em modelos experimentais de disfunções cardiometabólicas associadas à privação dos hormônios ovarianos
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/58942-0 - Da bancada à clínica: desenvolvimento de biomarcadores como preditores da resposta à terapêutica e lesão de órgãos-alvo na hipertensão arterial sistemática
• Beneficiário: Eduardo Moacyr Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático