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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions

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de Araujo Resende, Leandro Santos [1] ; Rabelo-Santos, Silvia Helena [2] ; Sarian, Luis Otavio [1] ; Figueiredo Alves, Rosane Ribeiro [3] ; Ribeiro, Andrea Alves [2] ; Zeferino, Luiz Carlos [1] ; Derchain, Sophie [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] State Univ Campinas UNICAMP, Fac Med Sci, Dept Obstet & Gynaecol, Campinas, SP - Brazil
[2] Univ Fed Goias, Sch Pharm, Goiania, Go - Brazil
[3] Univ Fed Goias, Dept Med, Catholic Univ Goias, Goiania, Go - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: BMC INFECTIOUS DISEASES; v. 14, APR 22 2014.
Citações Web of Science: 12

Background: Cervical cancer ranks third in prevalence and fourth as cause of death in women worldwide. In Brazil, 17,540 women were diagnosed in 2012 with the disease. Persistent infection with high-risk HPV types is a necessary condition for the development of pre-invasive and invasive cervical neoplasia. Currently, over 100 HPV types have been identified, but HPV16 and 18 are recognized as the mayor culprits in cervical carcinogenesis. Our objective was to assess the relationships between single-(ST) and multiple-type (MT) HPV infections with patients' age and lesion pathological status. Methods: 328 patients with either squamous or glandular intraepithelial or invasive cervical lesion were selected. All subjects were tested for HPV genotypes with reverse hybridization for 21 high-(hr-HPV) and 16 low-risk (lr-HPV) probes. Prevalence of ST and MT HPV infections was compared across histological types and age strata. Results: 287 (87%) women had at least one HPV type detected and 149 (52%) had MT infections. The most prevalent HPV type was HPV16, present in 142 cases (49% of all HPV-positive cases), followed by HPV58, 52, 31, 35 and 33. HPV18, in single or multiple infections, occurred in 23 cases (8% of hr-HPV cases). Almost all glandular lesions were associated with HPV16 and 18 alone. Multiple infections were significantly more prevalent in squamous than in glandular lesion for HPV16 and 18 (P = 0.04 and 0.03 respectively). The prevalence of MT infections followed a bimodal distribution; peaking in women younger 29 years and in those aged 50 to 59. Conclusions: Our data indicate that prevention strategies for pre-invasive and invasive squamous lesions should be focused on HPV16 and a few alpha-9 HPV types. It is clear to us that in young women, prophylaxis must cover a large amalgam of HPV types beyond classic HPV16 and 18. (AU)

Processo FAPESP: 12/15059-8 - Avaliação de biomarcadores para detecção de neoplasia maligna em mulheres com tumor anexial
Beneficiário:Sophie Françoise Mauricette Derchain
Linha de fomento: Auxílio à Pesquisa - Regular