Renoprotective effect of the Echinodorus macrophyllus in induced renal injury

Autor(es)

do Nascimento, Espedito Ladier ^[1] ; Watanabe, Mirian ^[1] ; da Fonseca, Cassiane Dezoti ^[1] ; Schlottfeldt, Fabio dos Santos ^[1] ; Fernandes Vattimo, Maria de Fatima ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Escola Enfermagem, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Acta Paulista de Enfermagem; v. 27, n. 1, p. 12-17, 2014.
• Citações Web of Science: 2

Resumo

Objective: Evaluating the renoprotective effect of Echinodorus macrophyllus in acute kidney injury induced by cyclophosphamide in rats. Methods: Experimental research with Wistar rats, male adults, distributed into groups, namely: Control administration of 1.5 ml sodium chloride 0.9% intraperitoneally; Echinodorous - administration of 2g/kg of Echinodorus macrophyllus by gavage for five days; Cyclophosphamide - administration of cyclophosphamide 150mg/kg intraperitoneally; and Cyclosphosphamide + Echinodorus - administration of Echinodorus macrophyllus and cyclophosphamide. Renal function (creatinine clearance) and the oxidative metabolites (peroxides and urinary substances reactive to thiobarbituric acid, thiols in kidney tissue) were evaluated. Results: Preconditioning with Echinodorus macrophyllus elevated the creatinine clearance and reduced the levels of oxidative metabolites. Conclusion: The antioxidant action of Echinodorus macrophyllus has demonstrated renoprotective effects evidenced by the reduction of oxidative stress in acute renal injury induced by cyclophosphamide in rats. (AU)

• Processo FAPESP: 10/02155-3 - O efeito do inibidor da fosfodiesterase tipo-5 e N-acetilcisteína na lesão renal aguda isquêmica em ratos
• Beneficiário: Maria de Fatima Fernandes Vattimo
• Linha de fomento: Auxílio à Pesquisa - Regular