| Full text | |
| Author(s): |
do Nascimento, Espedito Ladier
[1]
;
Watanabe, Mirian
[1]
;
da Fonseca, Cassiane Dezoti
[1]
;
Schlottfeldt, Fabio dos Santos
[1]
;
Fernandes Vattimo, Maria de Fatima
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Escola Enfermagem, Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Acta Paulista de Enfermagem; v. 27, n. 1, p. 12-17, 2014. |
| Web of Science Citations: | 2 |
| Abstract | |
OBJECTIVE: Evaluating the renoprotective effect of Echinodorus macrophyllusin acute kidney injury induced by cyclophosphamide in rats.METHODS: Experimental research with Wistar rats, male adults, distributed into groups, namely: Control - administration of 1.5 ml sodium chloride 0.9% intraperitoneally; Echinodorous - administration of 2g/kg of Echinodorus macrophyllus by gavage for five days; Cyclophosphamide - administration of cyclophosphamide 150mg/kg intraperitoneally; and Cyclosphosphamide + Echinodorus - administration of Echinodorus macrophyllus and cyclophosphamide. Renal function (creatinine clearance) and the oxidative metabolites (peroxides and urinary substances reactive to thiobarbituric acid, thiols in kidney tissue) were evaluated.RESULTS: Preconditioning with Echinodorus macrophyllus elevated the creatinine clearance and reduced the levels of oxidative metabolites.CONCLUSION: The antioxidant action of Echinodorus macrophyllus has demonstrated renoprotective effects evidenced by the reduction of oxidative stress in acute renal injury induced by cyclophosphamide in rats. (AU) | |
| FAPESP's process: | 10/02155-3 - Effect of the inhibitor of the fosfodiesterase 5 and N-acetylcisteine in the ischemic acute kidney injury in rats |
| Grantee: | Maria de Fatima Fernandes Vattimo |
| Support Opportunities: | Regular Research Grants |