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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Renoprotective effect of the Echinodorus macrophyllus in induced renal injury

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Author(s):
do Nascimento, Espedito Ladier [1] ; Watanabe, Mirian [1] ; da Fonseca, Cassiane Dezoti [1] ; Schlottfeldt, Fabio dos Santos [1] ; Fernandes Vattimo, Maria de Fatima [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Escola Enfermagem, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Acta Paulista de Enfermagem; v. 27, n. 1, p. 12-17, 2014.
Web of Science Citations: 2
Abstract

Objective: Evaluating the renoprotective effect of Echinodorus macrophyllus in acute kidney injury induced by cyclophosphamide in rats. Methods: Experimental research with Wistar rats, male adults, distributed into groups, namely: Control administration of 1.5 ml sodium chloride 0.9% intraperitoneally; Echinodorous - administration of 2g/kg of Echinodorus macrophyllus by gavage for five days; Cyclophosphamide - administration of cyclophosphamide 150mg/kg intraperitoneally; and Cyclosphosphamide + Echinodorus - administration of Echinodorus macrophyllus and cyclophosphamide. Renal function (creatinine clearance) and the oxidative metabolites (peroxides and urinary substances reactive to thiobarbituric acid, thiols in kidney tissue) were evaluated. Results: Preconditioning with Echinodorus macrophyllus elevated the creatinine clearance and reduced the levels of oxidative metabolites. Conclusion: The antioxidant action of Echinodorus macrophyllus has demonstrated renoprotective effects evidenced by the reduction of oxidative stress in acute renal injury induced by cyclophosphamide in rats. (AU)

FAPESP's process: 10/02155-3 - Effect of the inhibitor of the fosfodiesterase 5 and N-acetylcisteine in the ischemic acute kidney injury in rats
Grantee:Maria de Fatima Fernandes Vattimo
Support type: Regular Research Grants