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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Square-wave voltammetric determination of hydroxychloroquine in pharmaceutical and synthetic urine samples using a cathodically pretreated boron-doped diamond electrode

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Autor(es):
Deroco, Patricia Batista [1] ; Vicentini, Fernando Campanha [1] ; Oliveira, Geiser Gabriel [2] ; Rocha-Filho, Romeu C. [1] ; Fatibello-Filho, Orlando [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 719, p. 19-23, APR 1 2014.
Citações Web of Science: 31
Resumo

A square-wave voltammetry method for the determination of hydroxychloroquine (HCQ) in pharmaceutical and synthetic urine samples with a cathodically pretreated (CPT) boron-doped diamond (BDD) electrode was successfully developed. Using cyclic voltammetry, the HCQ oxidation was shown to be a one-electron diffusion-controlled process. The obtained SWVanalytical curve (I-pa/mu a = 0.033 + 1.24 {[}HCQ/mu mol L-1)]) for HCQ determination (using 0.1 mol L-1 H2SO4 as supporting electrolyte) presented a linear response from 0.1 to 1.9 mu mol L-1, with a detection limit of 0.06 mu mol L-1, the best value attained yet with an unmodified electrode. The proposed method was successfully applied in the determination of HCQ in pharmaceutical (tablets) samples, with results similar at a 95% confidence level to those obtained using a reference spectrophotometric method. Additionally, adequate recovery results were obtained for the determination of HCQ in doped synthetic urine samples. The novel proposed method is inexpensive and fast, with no need of sample pretreatment. (c) 2014 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 12/08180-5 - Desenvolvimento de métodos eletroanalíticos empregando o eletrodo de diamante dopado com boro para a determinação simultânea de edulcorantes e corantes em produtos alimentícios
Beneficiário:Patrícia Batista Deroco
Linha de fomento: Bolsas no Brasil - Mestrado