Square-wave voltammetric determination of hydroxychloroquine in pharmaceutical and synthetic urine samples using a cathodically pretreated boron-doped diamond electrode

Autor(es)

Deroco, Patricia Batista ^[1] ; Vicentini, Fernando Campanha ^[1] ; Oliveira, Geiser Gabriel ^[2] ; Rocha-Filho, Romeu C. ^[1] ; Fatibello-Filho, Orlando ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 719, p. 19-23, APR 1 2014.
• Citações Web of Science: 31

Resumo

A square-wave voltammetry method for the determination of hydroxychloroquine (HCQ) in pharmaceutical and synthetic urine samples with a cathodically pretreated (CPT) boron-doped diamond (BDD) electrode was successfully developed. Using cyclic voltammetry, the HCQ oxidation was shown to be a one-electron diffusion-controlled process. The obtained SWVanalytical curve (I-pa/mu a = 0.033 + 1.24 {[}HCQ/mu mol L-1)]) for HCQ determination (using 0.1 mol L-1 H2SO4 as supporting electrolyte) presented a linear response from 0.1 to 1.9 mu mol L-1, with a detection limit of 0.06 mu mol L-1, the best value attained yet with an unmodified electrode. The proposed method was successfully applied in the determination of HCQ in pharmaceutical (tablets) samples, with results similar at a 95% confidence level to those obtained using a reference spectrophotometric method. Additionally, adequate recovery results were obtained for the determination of HCQ in doped synthetic urine samples. The novel proposed method is inexpensive and fast, with no need of sample pretreatment. (c) 2014 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/08180-5 - Desenvolvimento de métodos eletroanalíticos empregando o eletrodo de diamante dopado com boro para a determinação simultânea de edulcorantes e corantes em produtos alimentícios
• Beneficiário: Patrícia Batista Deroco
• Modalidade de apoio: Bolsas no Brasil - Mestrado