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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Square-wave voltammetric determination of hydroxychloroquine in pharmaceutical and synthetic urine samples using a cathodically pretreated boron-doped diamond electrode

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Author(s):
Deroco, Patricia Batista [1] ; Vicentini, Fernando Campanha [1] ; Oliveira, Geiser Gabriel [2] ; Rocha-Filho, Romeu C. [1] ; Fatibello-Filho, Orlando [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 719, p. 19-23, APR 1 2014.
Web of Science Citations: 31
Abstract

A square-wave voltammetry method for the determination of hydroxychloroquine (HCQ) in pharmaceutical and synthetic urine samples with a cathodically pretreated (CPT) boron-doped diamond (BDD) electrode was successfully developed. Using cyclic voltammetry, the HCQ oxidation was shown to be a one-electron diffusion-controlled process. The obtained SWVanalytical curve (I-pa/mu a = 0.033 + 1.24 {[}HCQ/mu mol L-1)]) for HCQ determination (using 0.1 mol L-1 H2SO4 as supporting electrolyte) presented a linear response from 0.1 to 1.9 mu mol L-1, with a detection limit of 0.06 mu mol L-1, the best value attained yet with an unmodified electrode. The proposed method was successfully applied in the determination of HCQ in pharmaceutical (tablets) samples, with results similar at a 95% confidence level to those obtained using a reference spectrophotometric method. Additionally, adequate recovery results were obtained for the determination of HCQ in doped synthetic urine samples. The novel proposed method is inexpensive and fast, with no need of sample pretreatment. (c) 2014 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/08180-5 - DEVELOPMENT OF ELECTROANALYTICAL METHODS EMPLOYING A BORON-DOPED DIAMOND ELECTRODE FOR SIMULTANEOUS DETERMINATION OF SWEETENERS AND COLORANTS IN FOOD SAMPLES
Grantee:Patrícia Batista Deroco
Support Opportunities: Scholarships in Brazil - Master