Effects of fish oil on lipid profile and other metabolic outcomes in HIV-infected patients on antiretroviral therapy: a randomized placebo-controlled trial

Autor(es)

Oliveira, Julicristie M. ^[1] ; Rondo, Patricia Hc ^[2] ; Yudkin, John S. ^[3] ; Souza, Jose M. P. ^[4] ; Pereira, Tatiane N. ^[2] ; Catalani, Andrea W. ^[2] ; Picone, Camila M. ^[5] ; Segurado, Aluisio A. C. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Appl Sci, BR-13484350 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil

^[3] UCL, London - England

^[4] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Med, Dept Infect Dis, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF STD & AIDS; v. 25, n. 2, p. 96-104, FEB 2014.
• Citações Web of Science: 6

Resumo

Although antiretroviral therapy has revolutionized the care of HIV-infected patients, it has been associated with metabolic abnormalities. Hence, this study was planned to investigate the effects of fish oil on lipid profile, insulin resistance, and body fat distribution in HIV-infected Brazilian patients on antiretroviral therapy, considering that marine omega-3 fatty acids seem to improve features of the metabolic syndrome. We conducted a randomized, parallel, placebo-controlled trial that assessed the effects of 3 g fish oil/day (540 mg of eicosapentaenoic acid plus 360 mg of docosahexaenoic acid) or 3 g soy oil/day (placebo) on 83 HIV-infected Brazilian men and non-pregnant women on antiretroviral therapy. No statistically significant relationships between fish oil supplementation and longitudinal changes in triglyceride (p = 0.335), low- density lipoprotein cholesterol (p = 0.078), high-density lipoprotein cholesterol (p = 0.383), total cholesterol (p = 0.072), apolipoprotein B (p = 0.522), apolipoprotein Al (p = 0.420), low- density lipoprotein cholesterol/ apolipoprotein B ratio (p = 0.107), homeostasis model assessment for insulin resistance index (p = 0.387), body mass index (p = 0.068), waist circumference (p = 0.128), and waist/hip ratio (p = 0.359) were observed. A low dose of fish oil did not alter lipid profile, insulin resistance, and body fat distribution in HIV-infected patients on antiretroviral therapy. (AU)

• Processo FAPESP: 08/50970-8 - Efeito da suplementação com ômega-3 nos parâmetros inflamatórios, bioquímicos e cardiovasculares de adultos com HIV em HAART: ensaio clínico controlado, aleatorizado e duplo-cego
• Beneficiário: Patricia Helen de Carvalho Rondó
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/55532-9 - Efeito da suplementação com ômega-3 nos parâmetros inflamatórios, bioquímicos e cardiovasculares de adultos com HIV em HAART: ensaio clínico, aleatorizado, controlado e duplo-cego
• Beneficiário: Julicristie Machado de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado