nNOS polymorphisms are associated with responsiveness to sildenafil in clinical and postoperative erectile dysfunction

Autor(es)

Lacchini, Riccardo ^[1] ; Muniz, Jaqueline J. ^[2] ; Nobre, Yuri T. D. A. ^[3] ; Cologna, Adauto J. ^[3] ; Martins, Antonio C. P. ^[3] ; Tanus-Santos, Jose E. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dept Psychiat Nursing & Human Sci, Coll Nursing Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHARMACOGENOMICS; v. 15, n. 6, p. 775-784, APR 2014.
• Citações Web of Science: 9

Resumo

Aim: Sildenafil potentiates the nitric oxide (NO) signaling pathway. Since neuronal NOS is very important in the penis, we assessed whether NOS1 polymorphisms are associated with altered responsiveness to sildenafil in erectile dysfunction (ED). Materials \& methods: Patients (n = 137) were divided as clinical ED or postoperative ED. They were subdivided as good responders or poor responders to sildenafil, and genotypes for rs41279104 and rs2682826 NOS1 polymorphisms were determined. Results: We found that the rs41279104 CT genotype was associated with good responders in postoperative ED patients, while rs2682826 CT genotype was associated with good responders in postoperative ED, and the TT genotype associated with good responders in both groups. Finally, the CT haplotype was associated with good responders in postoperative ED. Conclusion: NOS1 polymorphisms are associated with responsiveness to sildenafil in ED. (AU)

• Processo FAPESP: 13/13346-2 - Relevância de polimorfismos genéticos da arginase para a disfunção erétil
• Beneficiário: Jose Eduardo Tanus dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Regular