| Texto completo | |
| Autor(es): |
R. Chinen
[1]
;
N.O.S. Câmara
[2]
;
S. Nishida
[3]
;
M.S. Silva
[4]
;
D.A. Rodrigues
[5]
;
A.B. Pereira
[6]
;
A. Pacheco-Silva
[7]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Universidade Federal de São Paulo. Disciplina de Nefrologia. Laboratório de Imunologia Clínica e Experimental
[2] Universidade Federal de São Paulo. Disciplina de Nefrologia. Laboratório de Imunologia Clínica e Experimental
[3] Universidade Federal de São Paulo. Disciplina de Nefrologia. Laboratório de Imunologia Clínica e Experimental
[4] Universidade Federal de São Paulo. Disciplina de Nefrologia. Laboratório de Imunologia Clínica e Experimental
[5] Universidade Federal de São Paulo. Disciplina de Cardiologia - Brasil
[6] Universidade Federal de São Paulo. Disciplina de Nefrologia. Laboratório de Imunologia Clínica e Experimental
[7] Universidade Federal de São Paulo. Disciplina de Nefrologia. Laboratório de Imunologia Clínica e Experimental
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Brazilian Journal of Medical and Biological Research; v. 39, n. 10, p. 1305-1313, 2006-10-00. |
| Resumo | |
Significant improvements have been noted in heart transplantation with the advent of cyclosporine. However, cyclosporine use is associated with significant side effects, such as chronic renal failure. We were interested in evaluating the incidence of long-term renal dysfunction in heart transplant recipients. Fifty-three heart transplant recipients were enrolled in the study. Forty-three patients completed the entire evaluation and follow-up. Glomerular (serum creatinine, creatinine clearance measured, and creatinine clearance calculated) and tubular functions (urinary retinol-binding protein, uRBP) were re-analyzed after 18 months. At the enrollment time, the prevalence of renal failure ranged from 37.7 to 54% according to criteria used to define it (serum creatinine > or = 1.5 mg/dL and creatinine clearance <60 mL/min). Mean serum creatinine was 1.61 ± 1.31 mg/dL (range 0.7 to 9.8 mg/dL) and calculated and measured creatinine clearances were 67.7 ± 25.9 and 61.18 ± 25.04 mL min-1 (1.73 m²)-1, respectively. Sixteen of the 43 patients who completed the follow-up (37.2%) had tubular dysfunction detected by increased levels of uRBP (median 1.06, 0.412-6.396 mg/dL). Eleven of the 16 patients (68.7%) with elevated uRBP had poorer renal function after 18 months of follow-up, compared with only eight of the 27 patients (29.6%) with normal uRBP (RR = 3.47, P = 0.0095). Interestingly, cyclosporine trough levels were not different between patients with or without tubular and glomerular dysfunction. Renal function impairment is common after heart transplantation. Tubular dysfunction, assessed by uRBP, correlates with a worsening of glomerular filtration and can be a useful tool for early detection of renal dysfunction. (AU) | |
| Processo FAPESP: | 04/08311-6 - Mecanismos moleculares, celulares e fisiopatológicos da insuficiência renal aguda |
| Beneficiário: | Nestor Schor |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |