| Texto completo | |
| Autor(es): Mostrar menos - |
Nakazone, Marcelo A.
[1]
;
De Marchi, Miguel A.
[1]
;
Pinhel, Marcela A. S.
[1]
;
Barros, Carolina F. D. C.
[1]
;
Julio, Maysa A. F.
[1]
;
Pinheiro, Anielli
[1]
;
Arazi, Simone S.
[2]
;
Hotta, Julia K.
[3]
;
Hirata, Mario H.
[2]
;
Hirata, Rosario D. C.
[2]
;
dos Santos, Jose E.
[3]
;
Souza, Doroteia R. S.
[1]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Fac Med Sao Jose Rio Preto, Dept Mol Biol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | GENETICS AND MOLECULAR BIOLOGY; v. 32, n. 2, p. 227-233, 2009. |
| Citações Web of Science: | 2 |
| Resumo | |
Xanthelasma might be a clinical manifestation of dyslipidemia, a recognized risk factor for coronary artery disease. We investigated the association of apolipoprotein E (APOE HhaI), apolipoprotein B (APOB XbaI and Ins/Del) and LDL receptor (LDLR AvaII and HincII) gene polymorphisms with lipid profiles in 100 Brazilians with xanthelasma and 100 controls. Allele frequencies were similar in both groups. APOE, APOB and LDLR genotypes were not correlated with differences in the serum lipid profile. In individuals with xanthelasma, the APOB D allele was associated with less chance of having increased LDL-cholesterol (O.R. = 0.16, CI95% = 0.03-0.94, p = 0.042). In the control group, the APOB X+ allele was associated with less chance of having both increased total cholesterol (O.R. = 0.16, CI95% = 0.03-0.78, p = 0.023) and increased LDL-cholesterol (O.R. = 0.10, CI95% = 0.02-0.60, p = 0.012). Moreover, there was a significantly higher frequency of control individuals (68%) with elevated serum triglyceride levels, compared to patients (48%, p = 0.008). On the other hand, triglyceride levels in controls also seemed to be influenced by all other gene polymorphisms studied, an effect that might be enhanced by environmental factors. (AU) | |
| Processo FAPESP: | 02/02545-0 - Variantes geneticas de apolipoproteinas b e e e receptor de ldl em pacientes com xantomas ou xantelasmas e seus familiares. |
| Beneficiário: | Dorotéia Rossi Silva Souza |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 02/02544-3 - Variantes genéticas da apolipoproteínas B e E e receptor de LDL de pacientes com xantomatoses |
| Beneficiário: | Marcelo Arruda Nakazone |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |