Physical training prevents body weight gain but does not modify adipose tissue gene expression

Autor(es)

Higa, T. S. ^[1] ; Bergamo, F. C. ^[2] ; Mazzucatto, F. ^[1] ; Fonseca-Alaniz, M. H. ^[3] ; Evangelista, F. S. ^{[1, 2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Escola Artes Ciencias & Humanidades, BR-03828000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Escola Educ Fis & Esporte, BR-03828000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Coracao, Dept Med LIM13, Fac Med, BR-03828000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 45, n. 10, p. 988-994, OCT 2012.
• Citações Web of Science: 5

Resumo

The relationship of body weight (BW) with white adipose tissue (WAT) mass and WAT gene expression pattern was investigated in mice submitted to physical training (PT). Adult male C57BL/6 mice were submitted to two 1.5-h daily swimming sessions (T, N = 18), 5 days/week for 4 weeks or maintained sedentary (S, N = 15). Citrate synthase activity increased significantly in the T group (P < 0.05). S mice had a substantial weight gain compared to T mice (4.06 +/- 0.43 vs 0.38 +/- 0.28 g, P < 0.01). WAT mass, adipocyte size, and the weights of gastrocnemius and soleus muscles, lung, kidney, and adrenal gland were not different. Liver and heart were larger and the spleen was smaller in T compared to S mice (P < 0.05). Food intake was higher in T than S mice (4.7 +/- 0.2 vs 4.0 +/- 0.3 g/animal, P < 0.05) but oxygen consumption at rest did not differ between groups. T animals showed higher serum leptin concentration compared to S animals (6.37 +/- 0.5 vs 3.11 +/- 0.12 ng/mL). WAT gene expression pattern obtained by transcription factor adipocyte determination and differentiation-dependent factor 1, fatty acid synthase, malic enzyme, hormone-sensitive lipase, adipocyte lipid binding protein, leptin, and adiponectin did not differ significantly between groups. Collectively, our results showed that PT prevents BW gain and maintains WAT mass due to an increase in food intake and unchanged resting metabolic rate. These responses are closely related to unchanged WAT gene expression patterns. (AU)

• Processo FAPESP: 09/52904-5 - Efeitos do treinamento fisico aerobio sobre a homeostasia glicemica em camundongos: papel da proteina ativada por amp (ampk).
• Beneficiário: Fabiana de Sant'Anna Evangelista
• Modalidade de apoio: Auxílio à Pesquisa - Regular