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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Prevalence and clinical significance of anti-ribosomal P antibody in childhood-onset systemic lupus erythematosus

Texto completo
Autor(es):
Aldar, H. [1] ; Lapa, A. T. ; Bellini, B. ; Sinicato, N. A. ; Postal, M. [5] ; Fernandes, P. T. ; Costallat, L. T. L. [7] ; Marini, R. [8] ; Appenzeller, S. [9]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas. Dept Med
[5] Univ Estadual Campinas. Dept Med
[7] Univ Estadual Campinas. Dept Med
[8] Univ Estadual Campinas. Dept Pediat
[9] Univ Estadual Campinas. Dept Med
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: Lupus; v. 21, n. 11, p. 1225-1231, OCT 2012.
Citações Web of Science: 4
Resumo

Objective: To investigate the prevalence of the anti-ribosomal P (anti-P) antibodies in childhood-onset systemic lupus erythematosus patients (cSLE), healthy controls and first degree relatives. To elucidate the association between anti-P and disease activity, laboratory and treatment features in cSLE patients. Methods: We included consecutive SLE patients with disease onset before 16 years. Controls were age- and sex-matched. SLE patients were assessed for clinical and laboratory SLE manifestations, disease activity (SLE Disease Activity Index (SLEDAI)), damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)) and current drug exposures. Mood disorders were determined through Becks Depression and Becks Anxiety Inventory. Anti-P measured by enzyme-linked immunosorbent assay. Results: We included 50 consecutive cSLE patients (mean age of 16.82 +/- 3.46 years), 35 first degree relatives (mean age of 38.73 +/- 3.89 years) and 20 health control (mean age of 18.3 +/- 4.97 years). Anti-P was observed in 13 (26%) cSLE patients and in no first-degree relative (p < 0.01) or control (p < 0.01). Anti-P was more frequently observed in patients with anxiety (p < 0.002). No other clinical, laboratory or treatment features, including SLEDAI and SDI scores were associated with the presence of anti-P in cSLE patients. Conclusion: Anti-P is frequently observed in cSLE patients and was associated with the presence of anxiety in this cohort of cSLE. Lupus (2012) 21, 1225-1231. (AU)

Processo FAPESP: 09/06049-6 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no Lúpus eritematoso sistêmico
Beneficiário:Simone Appenzeller
Linha de fomento: Bolsas no Brasil - Apoio a Jovens Pesquisadores
Processo FAPESP: 09/13046-3 - Análise da prevalência dos anticorpos anti-P, anti-NR2 e do marcador neuronal S100 beta no lúpus eritematoso sistêmico juvenil
Beneficiário:Henrique Aldar
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 08/02917-0 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no lúpus eritematoso sistêmico
Beneficiário:Simone Appenzeller
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores