Cholecalciferol Supplementation in Chronic Kidney Disease: Restoration of Vitamin D Status and Impact on Parathyroid Hormone

Autor(es)

Garcia-Lopes, Miriam G. ^[1] ; Pillar, Roberta ; Kamimura, Maria Ayako ^[3] ; Rocha, Lillian A. ; Canziani, Maria Eugenia F. ; Carvalho, Aluizio B. ; Cuppari, Lilian ^[7]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo. Nutr Program

^[3] Univ Fed Sao Paulo. Nutr Program

^[7] Univ Fed Sao Paulo. Div Nephrol

• Tipo de documento: Artigo Científico
• Fonte: ANNALS OF NUTRITION AND METABOLISM; v. 61, n. 1, p. 74-82, 2012.
• Citações Web of Science: 5

Resumo

Background/Aims: Hypovitaminosis D is highly prevalent among patients with chronic kidney disease (CKD) and has been associated with poor outcome. We aimed to test the effect of a protocol of cholecalciferol supplementation on the restoration of vitamin D status and on parathyroid hormone (PTH) levels in patients with CKD. Methods: This was a prospective interventional study of 6 months. Forty-five CKD patients (stages 3 and 4) with 25-hydroxyvitamin D deficiency {[}25(OH)D <15 ng/ml] were included. Patients received a weekly dose of 50,000 IU of cholecalciferol during 3 months, and 50,000 IU/month thereafter for those who had achieved 25(OH)D >= 30 ng/ml. Results: At 3 months, 78% of the patients restored their vitamin D status. At 6 months, only 43% of those patients maintained adequate vitamin D status. PTH decreased at 3 months (p = 0.02) but returned to baseline levels after 6 months. Fibroblast growth factor 23 increased at 3 months (p = 0.001) and returned to initial levels at 6 months. No changes were found in serum 1,25(OH)(2)D, ionized calcium and phosphorus. Conclusions: A weekly dose of 50,000 IU of cholecalciferol for 3 months restored the vitamin D status of most patients and led to a reduction in PTH. The monthly dose of 50,000 IU appears not to be sufficient to maintain the levels of 25(OH)D. Copyright (C) 2012 S. Karger AG, Basel (AU)

• Processo FAPESP: 06/03811-6 - Efeitos da suplementação com vitamina D2 sobre o metabolismo mineral ósseo de pacientes com doença renal crônica
• Beneficiário: Lilian Cuppari
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 06/55414-0 - Efeitos da suplementação com vitamina D2 sobre o metabolismo mineral ósseo de pacientes com doença renal crônica
• Beneficiário: Miriam Ghedini Garcia Lopes
• Modalidade de apoio: Bolsas no Brasil - Doutorado