Genes expressed in dental enamel development are associated with molar-incisor hypomineralization

Autor(es):Mostrar menos -

Jeremias, Fabiano ^[1] ; Koruyucu, Mine ^[2] ; Kuechler, Erika C. ^[3] ; Bayram, Merue ^[4] ; Tuna, Elif B. ^[5] ; Deeley, Kathleen ^[6] ; Pierri, Ricardo A. ^[7] ; Souza, Juliana F. ^[8] ; Fragelli, Camila M. B. ^[9] ; Paschoal, Marco A. B. ^[10] ; Gencay, Koray ^[11] ; Seymen, Figen ^[12] ; Caminaga, Raquel M. S. ^[13] ; dos Santos-Pinto, Lourdes ^[14] ; Vieira, Alexandre R. ^[15]

Afiliação do(s) autor(es):Mostrar menos -

^[1] Sao Paulo State Univ. Sch Dent Araraquara

^[2] Istanbul Univ. Fac Dent

^[3] Univ Pittsburgh. Sch Dent Med

^[4] Istanbul Univ. Fac Dent

^[5] Istanbul Univ. Fac Dent

^[6] Univ Pittsburgh. Sch Dent Med

^[7] Sao Paulo State Univ. Sch Dent Araraquara

^[8] Sao Paulo State Univ. Sch Dent Araraquara

^[9] Sao Paulo State Univ. Sch Dent Araraquara

^[10] Sao Paulo State Univ. Sch Dent Araraquara

^[11] Istanbul Univ. Fac Dent

^[12] Istanbul Univ. Fac Dent

^[13] Sao Paulo State Univ. Sch Dent Araraquara

^[14] Sao Paulo State Univ. Sch Dent Araraquara

^[15] Univ Pittsburgh. Sch Dent Med

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 58, n. 10, p. 1434-1442, OCT 2013.
• Citações Web of Science: 6

Resumo

Genetic disturbances during dental development influence variation of number and shape of the dentition. In this study, we tested if genetic variation in enamel formation genes is associated with molar-incisor hypomineralization (MIH), also taking into consideration caries experience. DNA samples from 163 cases with MIH and 82 unaffected controls from Turkey, and 71 cases with MIH and 89 unaffected controls from Brazil were studied. Eleven markers in five genes {[}ameloblastin (AMBN), amelogenin (AMELX), enamelin (ENAM), tuftelin (TUFT1), and tuftelin-interacting protein 11 (TFIP11)] were genotyped by the TaqMan method. Chi-square was used to compare allele and genotype frequencies between cases with MIH and controls. In the Brazilian data, distinct caries experience within the MIH group was also tested for association with genetic variation in enamel formation genes. The ENAM rs3796704 marker was associated with MIH in both populations (Brazil: p = 0.03; OR = 0.28; 95% C.I. = 0.06-1.0; Turkey: p = 1.22e-012; OR = 17.36; 95% C.I. = 5.98-56.78). Associations between TFIP11 (p = 0.02), ENAM (p = 0.00001), and AMELX (p = 0.01) could be seen with caries independent of having MIH or genomic DNA copies of Streptococcus mutans detected by real time PCR in the Brazilian sample. Several genes involved in enamel formation appear to contribute to MIH. (C) 2013 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 11/13636-5 - Avaliação genética da hipomineralização molar-incisivo
• Beneficiário: Lourdes Aparecida Martins dos Santos-Pinto
• Modalidade de apoio: Auxílio à Pesquisa - Regular