| Texto completo | |
| Autor(es): |
Romano, Camila M.
[1]
;
de Melo, Fernando L.
[2]
;
Corsini, Marco Aurelio B.
[3]
;
Holmes, Edward C.
[4]
;
Zanotto, Paolo M. de A.
[5]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo. Biomed Sci Inst ICBII
[2] Univ Sao Paulo. Biomed Sci Inst ICBII
[3] Univ Sao Paulo. Biomed Sci Inst ICBII
[4] Penn State Univ. Dept Biol
[5] Univ Sao Paulo. Biomed Sci Inst ICBII
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS One; v. 2, n. 10 OCT 10 2007. |
| Citações Web of Science: | 9 |
| Resumo | |
We detected 19 complete endogenous retroviruses of the K family in the genome of rhesus monkey (Macaca mulatta; RhERV-K) and 12 full length elements in the genome of the common chimpanzee (Pan troglodytes; CERV-K). These sequences were compared with 55 human HERV-K and 20 CERV-K reported previously, producing a total data set of 106 full-length ERV-K genomes. Overall, 61% of the human elements compared to 21% of the chimpanzee and 47% of rhesus elements had estimated integration times less than 4.5 million years before present (MYBP), with an average integration times of 7.8 MYBP, 13.4 MYBP and 10.3 MYBP for HERV-K, CERV-K and RhERV-K, respectively. By excluding those ERV-K sequences generated by chromosomal duplication, we used 63 of the 106 elements to compare the population dynamics of ERV-K among species. This analysis indicated that both HERV-K and RhERV-K had similar demographic histories, including markedly smaller effective population sizes, compared to CERV-K. We propose that these differing ERV-K dynamics reflect underlying differences in the evolutionary ecology of the host species, such that host ecology and demography represent important determinants of ERV-K dynamics. (AU) | |
| Processo FAPESP: | 00/04205-6 - Projeto VIRGEN - Viral Genetic Diversity Network (VGDN) |
| Beneficiário: | Paolo Marinho de Andrade Zanotto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |