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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Association between prehypertension, metabolic and inflammatory markers, decreased adiponectin and enhanced insulinemia in obese subjects

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Autor(es):
de Almeida, Amanda Roberta [1, 2] ; Monte-Alegre, Sarah [1, 2] ; Zanini, Michele Bianca [1, 2] ; Souza, Aglecio Luiz [1, 2] ; Etchebehere, Mauricio [1, 2] ; Rocha Gontijo, Jose Antonio [1, 2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Lab Metab Hidrossalino, Disciplina Med Interna, BR-13083592 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med, BR-13083592 Campinas, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: NUTRITION & METABOLISM; v. 11, JUN 2 2014.
Citações Web of Science: 9
Resumo

Background: Obesity is associated with development of the cardiorenal metabolic syndrome, which is a constellation of risk factors, such as insulin resistance, inflammatory response, dyslipidemia, and high blood pressure that predispose affected individuals to well-characterized medical conditions such as diabetes, cardiovascular and kidney chronic disease. The study was designed to establish relationship between metabolic and inflammatory disorder, renal sodium retention and enhanced blood pressure in a group of obese subjects compared with age-matched, lean volunteers. Methods: The study was performed after 14 h overnight fast after and before OGTT in 13 lean (BMI 22.92 +/- 2.03 kg/m(2)) and, 27 obese (BMI 36.15 +/- 3.84 kg/m(2)) volunteers. Assessment of HOMA-IR and QUICKI index were calculated and circulating concentrations of TNF-alpha, IL-6 and C-reactive protein, measured by immunoassay. Results: The study shows that a hyperinsulinemic (HI: 10.85 +/- 4.09 mu g/ml) subgroup of well-characterized metabolic syndrome bearers-obese subjects show higher glycemic and elevated blood pressure levels when compared to lean and normoinsulinemic (NI: 5.51 +/- 1.18 mu g/ml, P < 0.027) subjects. Here, the combination of hyperinsulinemia, higher HOMA-IR (HI: 2.19 +/- 0.70 (n = 12) vs. LS: 0.83 +/- 0.23 (n = 12) and NI: 0.98 +/- 0.22 (n = 15), P < 0.0001) associated with lower QUICKI in HI obese when compared with LS and NI volunteers (P < 0.0001), suggests the occurrence of insulin resistance and a defect in insulin-stimulated peripheral action. Otherwise, the adiponectin measured in basal period was significantly enhanced in NI subjects when compared to HI groups (P < 0.04). The report also showed a similar insulin-mediated reduction of post-proximal urinary sodium excretion in lean (LS: 9.41 +/- 0.68% vs. 6.38 +/- 0.92%, P = 0.086), and normoinsulinemic (NI: 8.41 +/- 0.72% vs. 5.66 +/- 0.53%, P = 0.0025) and hyperinsulinemic obese subjects (HI: 8.82 +/- 0.98% vs. 6.32 +/- 0.67%, P = 0.0264), after oral glucose load, despite elevated insulinemic levels in hyperinsulinemic obeses. Conclusion: In conclusion, this study highlights the importance of adiponectin levels and dysfunctional inflammatory modulation associated with hyperinsulinemia and peripheral insulin resistance, high blood pressure, and renal dysfunction in a particular subgroup of obeses. (AU)

Processo FAPESP: 09/52325-5 - Efeitos do exercício físico crônico de intensidade moderada nas vias de sinalização de insulina, inflamação e estresse oxidativo em indivíduos portadores de obesidade mórbida
Beneficiário:Sarah Monte Alegre
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/52696-0 - Estudo dos mecanismos envolvidos no desenvolvimento renal e na expressão hipocampo-hipotalamo-hipofisaria de receptores esteróides e dopaminérgicos em prole de ratas submetidas a restrição protéica gestacional
Beneficiário:Jose Antonio Rocha Gontijo
Linha de fomento: Auxílio à Pesquisa - Regular