| Texto completo | |
| Autor(es): |
Mesquita, Rickson C.
[1]
;
D'Souza, Angela
[2]
;
Bilfinger, Thomas V.
[3]
;
Galler, Robert M.
[4]
;
Emanuel, Asher
[5]
;
Schenkel, Steven S.
[6]
;
Yodh, Arjun G.
[7]
;
Floyd, Thomas F.
[8]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Penn. Dept Phys & Astron
[2] SUNY Stony Brook. Med Ctr
[3] SUNY Stony Brook. Med Ctr
[4] SUNY Stony Brook. Med Ctr
[5] SUNY Stony Brook. Med Ctr
[6] Univ Penn. Dept Phys & Astron
[7] Univ Penn. Dept Phys & Astron
[8] SUNY Stony Brook. Med Ctr
Número total de Afiliações: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS One; v. 8, n. 12 DEC 16 2013. |
| Citações Web of Science: | 12 |
| Resumo | |
Spinal cord ischemia can lead to paralysis or paraparesis, but if detected early it may be amenable to treatment. Current methods use evoked potentials for detection of spinal cord ischemia, a decades old technology whose warning signs are indirect and significantly delayed from the onset of ischemia. Here we introduce and demonstrate a prototype fiber optic device that directly measures spinal cord blood flow and oxygenation. This technical advance in neurological monitoring promises a new standard of care for detection of spinal cord ischemia and the opportunity for early intervention. We demonstrate the probe in an adult Dorset sheep model. Both open and percutaneous approaches were evaluated during pharmacologic, physiological, and mechanical interventions designed to induce variations in spinal cord blood flow and oxygenation. The induced variations were rapidly and reproducibly detected, demonstrating direct measurement of spinal cord ischemia in real-time. In the future, this form of hemodynamic spinal cord diagnosis could significantly improve monitoring and management in a broad range of patients, including those undergoing thoracic and abdominal aortic revascularization, spine stabilization procedures for scoliosis and trauma, spinal cord tumor resection, and those requiring management of spinal cord injury in intensive care settings. (AU) | |
| Processo FAPESP: | 12/02500-8 - Desenvolvimento de instrumentação e metodologias para monitoramento de oxigenação, fluxo sanguíneo e metabolismo cerebral com espectroscopias ópticas de difusão |
| Beneficiário: | Rickson Coelho Mesquita |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |