Estrogen replacement therapy and cognitive functions in healthy postmenopausal women: a randomized trial

Autor(es)

Gorenstein, Clarice ^{[1, 2, 3]} ; Renno, Jr., Joel ^[4] ; Guerra Vieira Filho, Antonio Helio ^[4] ; Gianfaldoni, Arlete ^[5] ; Goncalves, Marcelo Alfonso ^[5] ; Halbe, Hans Wolfgang ^[6] ; Fernandes, Cesar Eduardo ^[5] ; Demetrio, Frederico Navas ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pharmacol, Inst Biomed Sci, Sao Paulo - Brazil

^[2] Inst Psiquiatria, BR-05403010 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, HCFMUSP, Lab Psychopharmacol Clin Hosp, LIM 23, Sao Paulo - Brazil

^[4] HCFMUSP, Inst Psychiat, Sao Paulo - Brazil

^[5] FMUSP, Dept Gynecol & Obstet, Sao Paulo - Brazil

^[6] Med Sch Marilia, Dept Obstet & Gynecol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF WOMENS MENTAL HEALTH; v. 14, n. 5, p. 367-373, OCT 2011.
• Citações Web of Science: 15

Resumo

This study aimed to evaluate the effect of estrogen replacement therapy on verbal cognitive performance of middle-aged postmenopausal women. Middle-aged (40 to 59 years) hysterectomized, oligosymptomatic women receiving 0.625 mg/day of conjugated equine estrogens (N=27) or placebo (N=32) in a double-blind parallel group design were compared according to their performance on a verbal memory battery before and after six 28-day cycles of treatment. Both groups had similar age and educational level. The estrogen group performed better on digit span-forward and on the recall of the easy stimuli on the verbal-paired associates test regardless of age, education, physical symptoms, number of years of menopause, or blood estradiol levels. However, the small magnitude of difference in the effect on attentional span suggests that the estrogen-related improvement is unlikely to be of clinical relevance. Estrogen replacement therapy did not improve verbal memory in middle-aged, hysterectomized, postmenopausal, asymptomatic women. (AU)

• Processo FAPESP: 98/00730-7 - Estudo randomizado, duplo-cego de avaliação dos efeitos da terapia de reposição estrogênica sobre funções cognitivas e psicomotoras em mulheres menopausadas
• Beneficiário: Joel Reno Junior
• Modalidade de apoio: Bolsas no Brasil - Doutorado