Exploratory study of the effect of lifestyle counselling on bone mineral density and body composition in users of the contraceptive depot-medroxyprogesterone acetate

Autor(es)

Modesto, Waleska ^[1] ; Valeria Bahamondes, M. ^[1] ; dos Santos, Priscila Silva ^[1] ; Fernandes, Arlete ^[1] ; Dal'Ava, Natalia ^[1] ; Bahamondes, Luis ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Natl Inst Hormones & Womens Hlth, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE; v. 19, n. 4, p. 244-249, AUG 2014.
• Citações Web of Science: 5

Resumo

Objectives To compare variations in bone mineral density (BMD) and body composition (BC) in depot-medroxyprogesterone acetate (DMPA) users and nonusers after providing counselling on healthy lifestyle habits. Methods An exploratory study in which women aged 18 to 40 years participated: 29 new DMPA users and 25 new non-hormonal contraceptive users. All participants were advised on healthy lifestyle habits: sun exposure, walking and calcium intake. BMD and BC were assessed at baseline and 12 months later. Statistical analysis included the Mann-Whitney test or Student's t-test followed by multiple linear regression analysis. Results Compared to the controls, DMPA users had lower BMD at vertebrae L1 and L4 after 12 months of use. They also had a mean increase of 2 kg in total fat mass and an increase of 2.2% in body fat compared to the non-hormonal contraceptive users. BMD loss at L1 was less pronounced in DMPA users with a calcium intake >= 1 g/day compared to DMPA users with a lower calcium intake. Conclusions DMPA use was apparently associated with lower BMD and an increase in fat mass at 12 months of use. Calcium intake >= 1 g/day attenuates BMD loss in DMPA users. Counselling on healthy lifestyle habits failed to achieve its aims. (AU)

• Processo FAPESP: 11/01554-4 - Composição corporal e densidade mineral óssea de usuárias de acetato de medroxiprogesterona de depósito comparado ao dispositivo intrauterino diu tcu380a
• Beneficiário: Waleska Oliveira Modesto
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/53293-0 - Estudo prospectivo de avaliação da resistência insulínica, metabolismo de lípedes e repercussão subclínica de doença cardiovascular em mulheres que iniciam o uso do contraceptivo injetável trimestal de acetato de medroxiprogesterona de depósito em segmento de 2 anos
• Beneficiário: Luis Guillermo Bahamondes
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS