Determination of acetylsalicylic acid in commercial tablets by SERS using silver nanoparticle-coated filter paper

Autor(es)

Sallum, Loriz Francisco ^[1] ; Felipe Soares, Frederico Luis ^[1] ; Ardila, Jorge Armando ^[1] ; Carneiro, Renato Lajarim ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY; v. 133, p. 107-111, DEC 10 2014.
• Citações Web of Science: 15

Resumo

In this work, filter paper was used as a low cost substrate for silver nanoparticles in order to perform the detection and quantification of acetylsalicylic acid by SERS in a commercial tablet. The reaction conditions were 150 mM of ammonium hydroxide, 50 mM of silver nitrate, 500 mM of glucose, 12 min of the reaction time, 45 degrees C temperature, pretreatment with ammonium hydroxide and quantitative filter paper (1-2 mu m). The average size of silver nanoparticles deposited on the paper substrate was 180 nm. Adsorption time of acetylsalicylic acid on the surface of the silver-coated filter paper was studied and an adsorption time of 80 min was used to build the analytical curve. It was possible to obtain a calibration curve with good precision with a coefficient of determination of 0.933. The method proposed in this work was capable to quantify acetylsalicylic acid in commercial tablets, at low concentration levels, with relative error of 2.06% compared to the HPLC. The preparation of filter paper coated with silver nanoparticles using Tollen's reagent presents several advantages such as low cost of synthesis, support and reagents; minimum amount of residuals, which are easily treated, despite the SERS spectroscopy presenting fast analysis, with low sample preparation and low amount of reactants as in HPLC analysis. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/04321-3 - Avaliação da espectroscopia Raman amplificada por superfície em papel filtro e métodos quimiométricos na quantificação de fármacos
• Beneficiário: Loriz Francisco Sallum
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 10/16520-5 - Aplicação de métodos quimiométricos de calibração e resolução multivariada de curvas em espectroscopia Raman para análise qualitativa, quantitativa e de polimorfismo em fármacos
• Beneficiário: Renato Lajarim Carneiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular