15-deoxy-Delta(12,14)-prostaglandin J(2) reduces albumin-induced arthritis in temporomandibular joint of rats

Autor(es)

Quinteiro, Mariana Silva ^[1] ; Napimoga, Marcelo Henrique ^[2] ; Macedo, Cristina Gomes ^[1] ; Freitas, Fabiana Furtado ^[1] ; Abdalla, Henrique Balassini ^[1] ; Bonfante, Ricardo ^[1] ; Clemente-Napimoga, Juliana Trindade ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Lab Orofacial Pain, Piracicaba, SP - Brazil

^[2] Sao Leopoldo Mandic Inst & Res Ctr, Lab Immunol & Mol Biol, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Pharmacology; v. 740, p. 58-65, OCT 5 2014.
• Citações Web of Science: 14

Resumo

The aim of this study was to evaluate the peripheral effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) in albumin-induced arthritis in temporomandibular joint (TMJ) of rats. Antigen-induced arthritis (ALA) was generated in rats with methylated bovine serum albumin (mBSA) diluted in complete Freund's adjuvant. Pretreatment with an intra-articular injection of 15d-PGJ(2) (100 ng/TMJ) before mBSA intra-articular injection (10 mu g/TMJ) (challenge) in immunized rats significantly reduced the albumin-induced arthritis inflammation. The results demonstrated that 15d-PGJ(2) was able to inhibit plasma extravasation, leukocyte migration and the release of inflammatory cytokines IL-6, IL-12, IL-18 and the chemokine CINC-1 in the TMJ tissues. In addition, 15d-PGJ(2) was able to increase the expression of the anti-adhesive molecule CD55 and the anti-inflammatory cytokine IL-10. Taken together, it is possible to suggest that 15d-PGJ2 inhibit leukocyte infiltration and subsequently inflammatory process, through a shift in the balance of the pro- and anti-adhesive properties. Thus, 15d-PGJ2 might be used as a potential anti-inflammatory drug to treat arthritis-induced inflammation of the temporomandibular joint. (C) 2014 Published by Elsevier B.V. (AU)

• Processo FAPESP: 11/00683-5 - Avaliação do efeito periférico da 15d-PGJ2 no processo inflamatório induzido pela artrite reumatóide na articulação temporomandibular de ratos
• Beneficiário: Juliana Trindade Clemente Napimoga
• Modalidade de apoio: Auxílio à Pesquisa - Regular