| Full text | |
| Author(s): |
Quinteiro, Mariana Silva
[1]
;
Napimoga, Marcelo Henrique
[2]
;
Macedo, Cristina Gomes
[1]
;
Freitas, Fabiana Furtado
[1]
;
Abdalla, Henrique Balassini
[1]
;
Bonfante, Ricardo
[1]
;
Clemente-Napimoga, Juliana Trindade
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Lab Orofacial Pain, Piracicaba, SP - Brazil
[2] Sao Leopoldo Mandic Inst & Res Ctr, Lab Immunol & Mol Biol, Campinas, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | European Journal of Pharmacology; v. 740, p. 58-65, OCT 5 2014. |
| Web of Science Citations: | 14 |
| Abstract | |
The aim of this study was to evaluate the peripheral effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) in albumin-induced arthritis in temporomandibular joint (TMJ) of rats. Antigen-induced arthritis (ALA) was generated in rats with methylated bovine serum albumin (mBSA) diluted in complete Freund's adjuvant. Pretreatment with an intra-articular injection of 15d-PGJ(2) (100 ng/TMJ) before mBSA intra-articular injection (10 mu g/TMJ) (challenge) in immunized rats significantly reduced the albumin-induced arthritis inflammation. The results demonstrated that 15d-PGJ(2) was able to inhibit plasma extravasation, leukocyte migration and the release of inflammatory cytokines IL-6, IL-12, IL-18 and the chemokine CINC-1 in the TMJ tissues. In addition, 15d-PGJ(2) was able to increase the expression of the anti-adhesive molecule CD55 and the anti-inflammatory cytokine IL-10. Taken together, it is possible to suggest that 15d-PGJ2 inhibit leukocyte infiltration and subsequently inflammatory process, through a shift in the balance of the pro- and anti-adhesive properties. Thus, 15d-PGJ2 might be used as a potential anti-inflammatory drug to treat arthritis-induced inflammation of the temporomandibular joint. (C) 2014 Published by Elsevier B.V. (AU) | |
| FAPESP's process: | 11/00683-5 - Evaluation of the peripheral effect of 15d-PGJ2 on rheumatoid arthritis-induced inflammatory response in the TMJ of rats |
| Grantee: | Juliana Trindade Clemente Napimoga |
| Support Opportunities: | Regular Research Grants |