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Evaluation of microglial cells involvement in induction and persistence of inflammatory hypernociception induced by rheumatoid arthritis in rats TMJ

Grant number: 14/09975-7
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2014
Effective date (End): February 29, 2016
Field of knowledge:Biological Sciences - Physiology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Juliana Trindade Clemente Napimoga
Grantee:Ricardo Bonfante
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


The Rheumatoid Arthritis (RA) is a polyarthritis autoimmune that results in a chronic systemic inflammation affecting synovial joints such as the Temporomandibular Joint (TMJ) and being the pain the main complaint of patients. A previous study (FAPESP # 2011/18951-6) demonstrated that the RA induced experimentally in rat's TMJ causes a persistent hypernociception linked to the formation and maintenance of inflammatory pannus, result of an increase in the migration of inflammatory cells, edema, release of cytokines such as TNF - alpha and IL - 1beta and Intercellular Adhesion Molecule (ICAM 1). Considering that sensory disorders induced followed by neural and/or peripheral tissue injuries are associated with activation of microglia, the purpose of this study is to evaluate the expression and activity of the microglial cells on the trigeminal subnucleus caudal in the induction and development of persistent inflammatory hypernociception induced by RA in rat's TMJ. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BONFANTE, RICARDO; NAPIMOGA, MARCELO HENRIQUE; MACEDO, CRISTINA GOMES; ADBALLA, HENRIQUE BALLASSINI; PIERONI, VICTOR; CLEMENTE-NAPIMOGA, JULIANA TRINDADE. The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints. Neuroscience, v. 391, p. 120-130, NOV 1 2018. Web of Science Citations: 4.

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