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Evaluation of inflammatory hyperalgesia in the progression of rheumatoid arthritis experimentally induced on rats temporomandibular joint.

Grant number: 11/18951-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2012
Effective date (End): April 30, 2013
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal Investigator:Juliana Trindade Clemente Napimoga
Grantee:Ricardo Bonfante
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


Rheumatoid arthritis (RA) is a degenerative disorder, manifesting in many peripheral and symmetrically joints of the body including the temporomandibular joint (TMJ). The inflammatory process begins at the synovial membrane and extends to the articular surfaces, resulting in deformation and/or erosion of bones and cartilage. RA in TMJ causes pain, stiffness and restriction to its movement, which might harm the oral stomatognathic functions. Severe temporomandibular joint dysfunction related to RA can lead to serious consequences; therefore, the aim of this project is to investigate the progression of TMJ inflammatory process induced by RA in rats. The RA-induced inflammatory hyperalgesia will be measured, at different time intervals, by injecting formalin in the rats' TMJ and recording their behavior. The inflammatory progression will be evaluated considering such parameters as the neutrophil migration, the plasma extravasation, and the intercellular adhesion molecule (ICAM) expression. A histological analysis will be conducted to evaluate tissue degeneration. This project will contribute to a better understanding of disorders in the TMJ, resulting from an RA-induced inflammatory process. Also, it might aid in its diagnostic and the development of effective therapeutic approaches.Keywords: Rheumatoid Arthritis, Temporomandibular Joint, Hyperalgesia, Inflammation

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BONFANTE, RICARDO; NAPIMOGA, MARCELO HENRIQUE; MACEDO, CRISTINA GOMES; ADBALLA, HENRIQUE BALLASSINI; PIERONI, VICTOR; CLEMENTE-NAPIMOGA, JULIANA TRINDADE. The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints. Neuroscience, v. 391, p. 120-130, NOV 1 2018. Web of Science Citations: 4.

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