Vitamins and iron blood biomarkers are associated with blood pressure levels in European adolescents. The HELENA study

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Ferreira de Moraes, Augusto Cesar ^{[1, 2, 3]} ; Gracia-Marco, Luis ^{[3, 4]} ; Iglesia, Iris ^{[2, 3]} ; Gonzalez-Gross, Marcela ^{[5, 6]} ; Breidenassel, Christina ^{[5, 6]} ; Ferrari, Marika ^[7] ; Molnar, Denes ^[8] ; Gomez-Martinez, Sonia ^[9] ; Androutsos, Odysseas ^[10] ; Kafatos, Anthony ^[11] ; Cuenca-Garcia, Magdalena ^[12] ; Sjostrom, Michael ^[13] ; Gottrand, Frederic ^{[14, 15, 16]} ; Widhalm, Kurt ^[17] ; Carvalho, Heraclito Barbosa ^[1] ; Moreno, Luis A. ^{[1, 2, 3]}

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^[1] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil

^[2] Univ Zaragoza, Fac Hlth Sci, Zaragoza - Spain

^[3] Univ Zaragoza, GENUD Growth Exercise Nutr & Dev Res Grp, Zaragoza - Spain

^[4] Univ Exeter, Childrens Hlth & Exercise Res Ctr, Exeter, Devon - England

^[5] Tech Univ Madrid, Dept Hlth & Human Performance, Fac Phys Act & Sport INEF, Madrid - Spain

^[6] Univ Bonn, Inst Ernahrungs & Lebensmittelwissensch Humanerna, Bonn - Germany

^[7] Natl Res Inst Food & Nutr, Rome - Italy

^[8] Univ Pecs, Fac Med, Dept Paediat, Pecs - Hungary

^[9] Spanish Natl Res Council, Immunonutr Res Grp, Dept Metab & Nutr, Food Sci & Technol & Nutr Inst, Madrid - Spain

^[10] Harokopio Univ, Dept Nutr & Dietet, Athens - Greece

^[11] Univ Crete, Sch Med, Prevent Med & Nutr Unit, Iraklion, Crete - Greece

^[12] Univ Granada, Sch Med, Dept Med Physiol, Granada - Spain

^[13] Karolinska Inst, Dept Biosci, Unit Prevent Nutr, Stockholm - Sweden

^[14] Univ Lille Nord France, Lille - France

^[15] Unite Inserm U995, Lille - France

^[16] Ctr Invest Clin, Lille - France

^[17] Private Med Univ Salzburg, Dept Pediat, Salzburg - Austria

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 30, n. 11-12, p. 1294-1300, NOV-DEC 2014.
• Citações Web of Science: 7

Resumo

Objectives: Previous research showed that low concentration of biomarkers in the blood during adolescence (i.e., iron status; retinal; and vitamins B-6, B-12, C, and D) may be involved in the early stages of development of many chronic diseases, such as hypertension. The aim was to evaluate if iron biomarkers and vitamins in the blood are associated with blood pressure in European adolescents. Methods: Participants from the Healthy Lifestyle in Europe by Nutrition in Adolescence cross-sectional study (N = 1089; 12.5-17.5 y; 580 girls) were selected by complex sampling. Multilevel linear regression models examined the associations between iron biomarkers and vitamins in the blood and blood pressure; the analyses were stratified by sex and adjusted for contextual and individual potential confounders. Results: A positive association was found in girls between RBC folate concentration and systolic blood pressure (SBP) (beta = 3.19; 95% confidence interval {[}CI], 0.61-5.77), although no association between the vitamin serum biomarkers concentrations and diastolic blood pressure (DBP) was found. In boys, retinol was positively associated with DBP (beta = 3.84; 95% CI, 0.51-7.17) and vitamin B-6 was positively associated with SBP (beta = 3.82; 95% CI, 1.46-6.18). In contrast, holotranscobalamin was inversely associated with SBP (beta = -3.74; 95% CI, -7.28 to -0.21). Conclusions: Levels of RBC folate and vitamin B-6 in blood may affect BP in adolescents. In this context, programs aimed at avoiding high BP levels should promote healthy eating behavior by focusing on the promotion of vegetable proteins and foods rich in vitamin B-12 (i.e., white meat and eggs), which may help to achieve BP blood control in adolescents. (C) 2014 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 11/11137-1 - Pressão arterial elevada e agregação de fatores de risco em adolescentes: um estudo multicêntrico
• Beneficiário: Augusto César Ferreira de Moraes
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/20662-2 - Pressão arterial elevada e agregação de fatores de risco em adolescentes: um estudo multicêntrico
• Beneficiário: Augusto César Ferreira de Moraes
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado