Vitamin E Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy

Autor(es)

Itinoseki Kaio, Daniella J. ^[1] ; Rondo, Patricia Helen C. ^[1] ; Luzia, Liania Alves ^[1] ; Souza, Jose Maria P. ^[2] ; Firmino, Aline Vale ^[1] ; Santos, Sigrid Sousa ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, BR-01246904 Sao Paulo - Brazil

^[3] Univ Fed Sao Carlos, Dept Med, Ctr Biol & Hlth Sci, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRIENTS; v. 6, n. 9, p. 3641-3652, SEP 2014.
• Citações Web of Science: 3

Resumo

HIV/AIDS patients are probably more predisposed to vitamin E deficiency, considering that they are more exposed to oxidative stress. Additionally, there are an extensive number of drugs in the highly active antiretroviral therapy (HAART) regimens that may interfere with vitamin E concentrations. The objective of this study was to compare serum concentrations of alpha-tocopherol in 182 HIV/AIDS patients receiving different HAART regimens. The patients were divided into three groups according to regimen: nucleoside analog reverse-transcriptase inhibitors (NRTIs) + non-nucleoside analog reverse-transcriptase inhibitors (NNRTIs); NRTIs + protease inhibitors + ritonavir; NRTIs + other classes. Alpha-tocopherol was assessed by high-performance liquid chromatography. Multiple linear regression analysis was used to evaluate the effects of HAART regimen, time of use, and compliance with the regimen on alpha-tocopherol concentrations. Alpha-tocopherol concentrations were on average 4.12 mol/L lower for the NRTIs + other classes regimen when compared to the NRTIs + NNRTIs regimen (p = 0.037). A positive association (p < 0.001) was observed between alpha-tocopherol and cholesterol concentrations, a finding due, in part, to the relationship between liposoluble vitamins and lipid profile. This study demonstrated differences in alpha-tocopherol concentrations between patients using different HAART regimens, especially regimens involving the use of new drugs. Long-term prospective cohort studies are needed to monitor vitamin E status in HIV/AIDS patients since the beginning of treatment. (AU)

• Processo FAPESP: 08/56395-5 - Verificacao das concentracoes sanguineas das vitaminas antioxidantes a e e em adultos com hiv/aids em terapia antiretroviral de alta potencia - haart
• Beneficiário: Patricia Helen de Carvalho Rondó
• Modalidade de apoio: Auxílio à Pesquisa - Regular