Human papillomavirus infection in oral fluids of HIV-1-positive men: prevalence and risk factors

Autor(es)

Gaester, Karen ^{[1, 2]} ; Fonseca, Luiz A. M. ^[3] ; Luiz, Olinda ^[3] ; Assone, Tatiane ^{[1, 2]} ; Fontes, Adriele Souza ^{[1, 2]} ; Costa, Fernando ^{[1, 2]} ; Duarte, Alberto J. S. ^{[1, 2]} ; Casseb, Jorge ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies, Sao Paulo - Brazil

^[2] Inst Trop Med, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 4, OCT 17 2014.
• Citações Web of Science: 11

Resumo

Human papillomavirus is one of the most common sexually transmitted diseases worldwide. The natural history of oral HPV infection is unclear, and its risk factors have not been explored. Immunocompromised individuals, as exemplified by HIV patients, are at high risk for HPV-related diseases. The mean of this study is to determine the prevalence ofHPV in the oral tract of HIV-1-positive male subjects and its association with risk factors. A total of 283 oral wash samples from HIV-1-positive men were tested. The oral fluid samples were used for DNA extraction and conventional PCR amplification; HPV genotyping was performed by hybridization. HPV genotyping revealed that nine samples (3.5%) were positive for HPV DNA; the major high-risk HPV types identified were 51 and 66. Worldwide studies have shown a variable prevalence of oral HPV. The diversity of genotypes and the high prevalence of multiple infections in HIV-infected subjects can be better explained by the effects of HIV-induced immunosuppression. The most important risk factors are unprotected sexual intercourse, but other factors for this infection have been described elsewhere including smoking, age and HIV-positive serostatus. In this study, smoking was the most important risk factor for acquiring oral HPV in HIV-1-infected subjects in Brazil. (AU)

• Processo FAPESP: 10/07076-4 - Avaliação da prevalência e mecanismos de resposta imune ao papilomavírus humano (HPV) em homens infectados pelo HIV-1 na Cidade de São Paulo, Brasil
• Beneficiário: Jorge Simao do Rosario Casseb
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/16094-9 - Prevalência do HPV no fluído oral em homens infectados pelo HIV-1 e fatores de risco relacionados à infecção.
• Beneficiário: Karen Eliane de Oliveira Gaester
• Modalidade de apoio: Bolsas no Brasil - Mestrado