Frozen pulp extracts of camu-camu (Myrciaria dubia McVaugh) attenuate the hyperlipidemia and lipid peroxidation of Type 1 diabetic rats

Autor(es)

de Souza Schmidt Goncalves, Any Elisa ^[1] ; Lellis-Santos, Camilo ^[2] ; Curi, Rui ^[2] ; Lajolo, Franco Maria ^[1] ; Genovese, Maria Ines ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Food & Expt Nutr, BR-05508900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food Research International; v. 64, p. 1-8, OCT 2014.
• Citações Web of Science: 13

Resumo

Several epidemiological and experimental studies demonstrate that modulation of inflammatory response and oxidative stress by natural phytochemicals is a promising strategy to prevent and treat many chronic inflammatory diseases. Camu-camu is an Amazonian fruit with a high content of antioxidants, especially phenolic compounds and vitamin C. In the present study we evaluated the in vivo effects of chronic ingestion of raw extracts derived from camu-camu (Myrciaria dubia McVaugh) frozen pulp on plasma lipid profile and oxidative stress in streptozotocin-induced diabetic rats. Oral administration of camu-camu raw extracts significantly increased plasma antioxidant activity, reduced triacylglycerol and total cholesterol and lipid peroxidation in the plasma of streptozotocin-induced diabetic rats. However, no effect was observed on glucose metabolism of diabetic rats, probably due to the severity of this model. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 10/52192-2 - Descoberta de moléculas bioativas de extratos de plantas e frutas do Canadá e Brasil com propriedades terapêuticas no combate a obesidade, diabetes e doenças cardiovasculares
• Beneficiário: Franco Maria Lajolo
• Modalidade de apoio: Auxílio à Pesquisa - Regular